libera/##covid-19/ Thursday, 2021-09-02

trbpLjL: ultrasound and double monitoring o2 sturation and heartmonitoring for at least 1,5h, another one with the usal paperwork about 5 mins for the doctors to swipe through, but the lady said, with your myo/peri if it is/was i will tell you right now we wont find it so fast now...00:00
LjLhonestly don't know how they'd find it00:00
trbpadvising cardio-mrt00:00
LjLthat sounds like they did a somewhat thorough job00:00
trbpwell problem is i guess not all is covered by standard insurance00:01
trbpand it is an er00:01
LjL:(00:01
trbpstill i trust that what she did was/is ok00:01
LjLjust take it easy and don't try to exercise strenuously in case it's myocarditis or similar00:02
LjLi don't really know how it's diagnosed00:02
trbpstill the blood report, does only cover standard measureing for i.e. standard inflammations and that obviously was gone after 3 days00:02
trbpi made some research00:02
trbpand her hints helped too00:02
trbpif it was acute active she could have heard read something maybe because of irregularity out of bounds00:03
trbphad one or inactive cardio mrt and special heart enzymatics (which i cannot see in the report checked) could help00:03
trbpproblematic is i am also autoimmune psoriasis00:09
nixonixOur results show that HCoV-specific, SARS-CoV-2-cross-reactive T cells contribute to SARS-CoV-2 immune responses upon infection and vaccination. Additionally, such cognate cross-reactivity correlates with a rapid cellular and enhanced humoral response, which may both favor mild disease courses.00:09
nixonixso, you took pcr test?00:10
nixonixConversely, in the elderly, with waning HCoV T cell reactivity and thus reduced SARS-CoV-2 T cell cross-reactivity, additional booster vaccinations may be critical00:10
trbpall in all it can come from anywhere, but if you ask me i am one of the unlucky low percentage ones00:10
nixonixThe immunodominant cross-reactive peptide (S816-830) identified here is located within the highly conserved spike fusion peptide domain downstream of the S2′ cleavage site00:10
nixonixits about 2 per million in age group of 40-49, they found myo/pericarditis. less with pfizer. and it didnt exceed normal background cases. so highly unlikely caused by mrna vaccine, in that age group00:11
nixonixill find the link in a min, but this is an interesting study on hcov crossreactivity improving vaccine protection00:12
trbpnixonix: they did pcr anti-gen heck the second hospital i went on monday even looked for multireseitent stuff....00:12
nixonixit has been proposed that antibodies specific to the S2 portion of spike possess neutralizing activity and may be involved in the early induction of protection before SARS-CoV-2-S1-specifc antibodies emerged (28, 41–43). In summary, the S816-830 peptide may serve as a conserved universal coronavirus target in the S2 portion of spike for both B00:12
nixonixcells and T cells00:12
nixonixantigen test, which prob doesnt show low viral loads, and should be taken in early symptoms00:13
nixonix.title https://www.science.org/doi/10.1126/science.abh182300:13
Brainstormnixonix: From www.science.org: Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination00:13
nixonixbut then theres that hypothesis, that kids with no/low cellular cross-reactivity against hcovs, might explain milders symptoms in sars2 infection. things might be different with vaccine, so that crossreactivity would be beneficial00:14
nixonixi read that drosten thought crossreactivity was negligible00:16
nixonixbut opinions on that have gone back and forth among experts. like i think balloux said he was changing his mind00:17
nixonixwhile not immunologist00:17
nixonixi guess this one (slides on myocarditis due to mrna vaccination, age groups): https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-06/03-COVID-Shimabukuro-508.pdf00:20
BrainstormNew from r/WorldNews: worldnews: North Korea rejects offer of almost three million Covid-19 jabs → https://is.gd/s6kf7I00:28
nixonixljl asked over year ago, would it be good to get some hcov infection, so that would give some protection from sars2. i thought no, since it looked like it would not protect, and there could even be harmful interference00:28
nixonixnow its possible, that it might have been good idea, for enhanced vaccine protection. so i guess i take that back (:00:28
LjLwell it's okay since i don't remember asking00:29
nixonixi remember, because im on l-theanine, and it feels awesome!00:31
nixonixIn July, it rejected shipments of around two million doses of the AstraZeneca jab, citing concerns over potential side effects00:31
nixonixthat one they turned elsewhere, was Sinovac00:32
nixonixthey havent wanted sputnik either00:32
nixonixi guess mrna vaccines with their small chance of mostly mild heart inflammation, would be too risky also00:33
de-facto.title https://www.science.org/doi/10.1126/sciimmunol.abl434000:33
Brainstormde-facto: From www.science.org: Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths00:33
nixonixdespite with current evidence, not single proven deaths induced by mrna vaccine (excluding old and fragile, which are very hard to find out the main reason of death), so belonging to the safest vaccines in history most likely00:34
nixonixas far is i know, and i tried to look for myo/pericarditis or allergic reaction deaths another day. it looks like not single one registered00:35
nixonixexp those suspected cases among old and fragile. but meaning because of the above reasons, my googling00:36
nixonixand when CDC used to have a standard 6 months vaccine safety data after the last shot in 3rd phase trials, and 12 months for adjuvanted vaccines - and because millions were dying of sars2 they accepted 2 months - it would be odd to say the least that suddenly something like 3 years would have been required for these vaccines. while tens of millions00:38
nixonixwould have likely died waiting00:38
BrainstormNew from StatNews: Vaccination reduces risk of long Covid, even when people are infected, U.K. study indicates: People who are fully vaccinated against Covid-19 appear to have a much lower likelihood of developing long Covid than unvaccinated people even when they contract the coronavirus, according to a… → https://is.gd/qp0S4w00:38
nixonixmy quick estimate, currently over 1B pfizer doses administered - maybe 1.5B or so total mrna, prevented at least 1 million deaths. but since most of westerners are now vaccinated, the protection continues, the case numbers have been lower etc, the number is actually larger already, that they have prevented00:40
LjL“We found that the odds of having symptoms for 28 days or more after post-vaccination infection were approximately halved by having two vaccine doses,”  ← MUCH LOWER00:40
LjLi don't know when science decided that "much lower" didn't mean like an order of magnitude anymore00:40
nixonixand how many deaths have they caused, excluding old and fragile? somewhere between 0-1000 i suppose. theres probably no single non-vaccine drug with as good harm-benefit ratio, excluding antibiotics i guess00:41
nixonixrant off00:41
BrainstormUpdates for Germany: +6340 cases (now 4.0 million) since 17 hours ago — Bulgaria: +1745 cases (now 457487), +54 deaths (now 18950), +24834 tests (now 4.3 million) since 21 hours ago — Kenya: +1018 cases (now 236881), +13 deaths (now 4739), +9347 tests (now 2.4 million) since 23 hours ago — Canada: +1974 cases (now 1.5 million), +17 deaths (now 26967) since 21 hours ago00:41
nixonixit depends, for a drug that reduces severe cases mortality by 10%, its an awesome result00:43
nixonixi dont care about perceived lc symptoms, that usually but not always get milder during the months. but the permanent organ damage. without good information on that, they just let it rip through unvaccinated kids and those not yet fully vaccinated00:46
trbpnixonix: sometimes ones needs are higher than the needs of all others, are they not? :)00:47
trbpi don't care you don't care he she it doesn't care and so on, and numbers are nice relative absolute jump here jump there...00:49
trbpsometimes hearing scientists i feel like attending a bible group00:50
trbpthat said, there always is good science, a pity that it is today mostly not to find as easy and stands behind all the profitable quick solutions to shine bright like diamonds...00:51
trbpi guess if we take anything and could press it as hard as possible we could make out of anything a nice and shiny bright diamond...00:51
trbpof course it is not such as easy... and it is an exaggeration, but is carelessness not also a kind of exaggeration?00:56
trbpand since when did scientists start not to care anymore?00:57
BrainstormNew from r/WorldNews: worldnews: WHO monitoring new coronavirus variant named 'Mu' → https://is.gd/DB9SBN01:00
nixonix.title https://twitter.com/ahandvanish/status/138714039279407923601:00
Brainstormnixonix: From twitter.com: Hannah Davis 🌈 (@ahandvanish): "Antibody testing to diagnose #LongCOVID disenfranchises women! 1) Males are 4x more likely to retain antibodies 2) 36% of females lost antibodies by 3-6 months vs 8% [...]01:00
nixonix.title https://twitter.com/ahandvanish/status/1430614546356621315  includes link to the study01:02
Brainstormnixonix: From twitter.com: Hannah Davis 🌈 (@ahandvanish): "From the CDC: In COVID patients with low baseline antibody levels (more common in "mild" cases & in women), 65% lost their antibodies by 60 days post-onset! If your [...]01:02
nixonixso without PCR test, when you look for lc treatment, they will give you NLP instead...01:06
nixonixand say, like its said in lc clinic guidance slides here, that more laboratory tests should not be done, because they will predispose the patient to nocebo loop (thinking its some biological, instead of just psychosomatic, for which they have NLP and whole the nine yards ready)01:09
BrainstormNew from Eric Topol: @EricTopol: New @TheLancet The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01699-8/fulltext → https://is.gd/yh3kHV01:10
nixonix"after an extended interval (44–45 weeks) between the first and second dose" - did they check that they didnt get rona infection during that 10 months, between the doses?01:15
nixonixlooks like some pcr test positives were excluded, and at least with quick search didnt find anything about serological tests for N or something01:20
nixonixdoesnt have "nucleocapsid" "n-protein" "n protein" in the text01:21
BrainstormUpdates for Bahamas: +27 deaths (now 381) since 2 days ago — Papua New Guinea: +24 cases (now 17862) since 8 days ago01:31
nixonix.title https://twitter.com/FabreAlexandre1/status/142562560449439744101:38
Brainstormnixonix: From twitter.com: Fabre Alexandre (@FabreAlexandre1): "as in vitro study suggest a nearly identical decrease of neutralizing antibody between both vaccine against delta the most parsimonious is probably either waning [...]01:38
nixonix.title https://twitter.com/DrNaderKHijazi1/status/1425176263262670848  Anyone knows, what study is this from? IgA...01:43
Brainstormnixonix: From twitter.com: Dr Nader K. Hijazi (@DrNaderKHijazi1): "I am not sure why it’s not clicking with many about what’s unfolding: #waning_immunity IgA <18% peak level >3m so ⬆️mucosal infection + transmission, IgG<50% [...]01:43
nixonix.title https://twitter.com/fitterhappierAJ/status/143307606771204506101:54
Brainstormnixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "I agree. One group showed IM vaccs can create antibodies in saliva that coat mucosal surfaces but the effect was transient. We need something more [...]01:54
nixonixdudes, tell me what you know about ronavaxes and IgA. mucosal dimeric IgA or only monomeric in blood?01:56
nixonix"The present data underscore the current knowledge gap surrounding COVID-19 mRNA vaccine-induced IgA production and distribution at mucosal sites.01:59
nixonix.title https://www.spandidos-publications.com/10.3892/mmr.2021.1221702:04
Brainstormnixonix: From www.spandidos-publications.com: COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers02:04
dTalabsoluely bugger all, don't even know where I'd buy a mucosal demerera02:09
nixonixwhatwhat, is that some kind of sugar?02:10
nixonixfound the paper where those pics are from. but thanks for all helping02:11
nixonix.title https://journals.plos.org/plosone/article?id=10.1371/journal.pone.024949902:12
Brainstormnixonix: From journals.plos.org: Human IgG and IgA responses to COVID-19 mRNA vaccines02:12
nixonixanyways, that dude is wrong about thinking serum IgA (that is monomeric, weak, could possibly even reduce the protection of stronger IgG by binding to sites where IgG would be more effective - and afaik has no cell-mediated effector functions) waning02:16
nixonixit could be about dimeric IgA on mucosa, but i havent found anything about im vaccines inducing them. maybe not, because nobody seems interested in IgA02:17
BrainstormNew from NPR: Moderna Has Asked The FDA To Authorize A Booster Of Its COVID-19 Vaccine: Moderna submitted data from 344 volunteers who got a third shot of the vaccine six months after their first two doses. The additional shot significantly boosted immunity, the company said. → https://is.gd/hNeCEX02:25
BrainstormUpdates for Norway: +1640 cases (now 161814) since 23 hours ago — Cabo Verde: +152 cases (now 35506), +1 deaths (now 314) since a day ago — France: +9881 cases (now 6.8 million), +2966 deaths (now 117487) since 23 hours ago — Kazakhstan: +4349 cases (now 827606), +2746 deaths (now 12655) since 23 hours ago02:33
BrainstormNew from r/WorldNews: worldnews: Moderna to recall COVID-19 doses in Japan after stainless steel contaminants found → https://is.gd/NQfdfq03:51
CHALK_MIRCanyone here need some food?..ive got some food i want to gift out03:56
BrainstormUpdates for Benin: +2566 cases (now 15932), +3 deaths (now 131) since 5 days ago — Ivory Coast: +479 cases (now 56148), +4 deaths (now 445) since a day ago — Egypt: +291 cases (now 288732), +7 deaths (now 16743) since a day ago — Channel Islands: +41 cases (now 10649), +19199 tests (now 829028) since a day ago04:00
CHALK_MIRCus only please...thanks and thats where im at.04:03
jacklswwhere in US?04:12
jacklswirc users are worldwide :D04:12
BrainstormUpdates for Mexico: +17337 cases (now 3.4 million), +1177 deaths (now 260503), +45488 tests (now 9.8 million) since 23 hours ago — United Kingdom: +34720 cases (now 6.8 million), +168 deaths (now 132852) since 23 hours ago — France: +9431 cases (now 6.8 million), +2962 deaths (now 117508) since 23 hours ago — Netherlands: +2791 cases (now 2.0 million), +9 deaths (now 18191) since 23 hours ago04:37
CHALK_MIRCare you sending me reports on covid rn?04:41
BrainstormUpdates for Peru: +196 cases (now 2.2 million), +1 deaths (now 198296), +41770 tests (now 16.8 million) since 19 hours ago05:41
BrainstormNew from Politico: Climate change worries fuel nuclear dreams: Concern over global warming is reopening the debate about shutting down nuclear power plants. → https://is.gd/X3XCAl06:09
BrainstormNew from This Week In Virology: TWiV 799: A very model of a modern TWiV: TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. → https://is.gd/KM5BEa06:20
BrainstormNew from Eric Topol: @EricTopol: The kidneys are not getting enough attention in #LongCovid. A new, large study of ~90,000 people w/ Covid @DeptVetAffairs and controlshttps://jasn.asnjournals.org/content/early/2021/08/25/ASN.2021060734 by @zalaly and colleagues @ASNKidney https://www.nytimes.com/2021/09/01/health/covid-kidney-damage.html by @PamBelluck → https://is.gd/pVdotI06:31
BrainstormNew from The Indian Express: World: Another hidden Covid risk: lingering kidney problems → https://is.gd/RZntjZ07:03
BrainstormUpdates for Pakistan: +4103 cases (now 1.2 million), +89 deaths (now 25978), +61651 tests (now 17.9 million) since 23 hours ago — Germany: +9591 cases (now 4.0 million), +20 deaths (now 92562) since 23 hours ago07:08
BrainstormNew from r/WorldNews: worldnews: New Zealand police surround address after Covid-positive man escapes quarantine → https://is.gd/r5ESFC07:55
BrainstormUpdates for Iowa, United States: +8308 cases (now 408390), +39 deaths (now 6307) since 7 days ago — Ohio, United States: +7102 cases (now 1.2 million) since a day ago — Osaka, Japan: +3004 cases (now 171740), +12 deaths (now 2801) since a day ago — Baden-Wurttemberg, Germany: +2303 cases (now 530595), +6 deaths (now 10481) since a day ago08:10
twomoondamn NZ swatting a house because of a covid positive dude08:33
twomoonDarwin was right that weird things happen evolutionarily on islands08:34
BrainstormNew from r/WorldNews: worldnews: Queensland family refuses testing, forcing entire school into isolation as new local case is recorded → https://is.gd/mt5u8S08:37
SpearRavenhttps://www.youtube.com/watch?v=BVHVz377Q6U09:08
SpearRavenMan who preached COVID was a myth now in hospital with the virus | 7NEWS09:09
BrainstormNew from r/Coronavirus: Daily Discussion Thread | September 02, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/ttIHR509:09
archpcSpearRaven, I don’t really have any sympathy for them anymore09:14
archpcMy spO2 has stabilized at 92-93 for the last few days also, I can tell my lungs kinda took a hit09:17
BrainstormNew from The Indian Express: World: Pandemics get forgotten, but not at this museum → https://is.gd/dx3T7Z09:30
undefined_bobarchpc: thats kinda low :O09:30
archpcIt was much lower before :D09:31
undefined_bobhow low? :o09:31
archpcUpper 70s09:37
BrainstormUpdates for Mongolia: +2539 cases (now 221351), +4 deaths (now 948) since 2 hours ago — India: +89057 cases (now 32.9 million), +868 deaths (now 439369) since 23 hours ago — Grenada: +125 cases (now 664), +1 deaths (now 3) since 23 hours ago — Czechia: +262 cases (now 1.7 million), +90295 tests (now 36.1 million) since 23 hours ago09:37
undefined_bobarchpc: not so good :( How did it feel like?09:38
twomoonthat's good archpc09:45
archpcI felt like a literal zombie09:46
twomoondamn09:46
undefined_bobzombies are bad09:50
BrainstormNew from EMA: News and press releases: (news): ECDC and EMA highlight considerations for additional and booster doses of COVID-19 vaccines, , 02/09/2021 → https://is.gd/XJDjko10:02
pwr22https://www.reddit.com/r/science/comments/pfwxnn/a_breathing_tube_through_the_rectum_could_be_an/10:03
pwr22We're saved!10:03
* archpc clenches10:06
pwr22"archpc's sats are dropping - quick get the respiratory butt plug!"10:07
archpcI’d rather die :|10:08
undefined_boblol yeah I read about that the other day :D10:09
BrainstormNew from EMA: What's new: General: COVID-19: latest updates → https://is.gd/ejWHzQ10:13
BrainstormNew from StatNews: The debate over Covid-19 vaccine boosters, what to call them, and whether they’re needed: U.S. health officials want you to get another shot of Covid-19 vaccine. But some experts in the vaccine world don’t think we should be using the B word to describe… → https://is.gd/BpPwb010:44
BrainstormNew from BMJ: Covid-19: UK will offer third vaccine dose to severely immunosuppressed people: The UK’s Joint Committee on Vaccination and Immunisation (JCVI) has recommended that people with severely weakened immune systems should have a third vaccine dose as part of their primary vaccination... → https://is.gd/g1WKpb11:27
BrainstormUpdates for Kerala, India: +32803 cases (now 4.1 million), +173 deaths (now 20961) since a day ago — Germany: +17060 cases (now 4.0 million), +213 deaths (now 92757) since 18 hours ago — Mizoram, India: +1992 cases (now 61111), +1 deaths (now 218) since a day ago — Lithuania: +807 cases (now 300339), +10 deaths (now 4579) since a day ago11:29
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: COVID-19 vaccine 'medical exemptions' are the new emotional support animals: anti-vaxxers need to take accountability for their stances and not hide behind the language of others' real medical conditions → https://is.gd/5HYSYI11:59
BrainstormNew from BMJ: Covid-19: 80% of young adults in UK are likely to have antibodies, data suggest: Around eight in ten young adults in the UK are now likely to have SARS-CoV-2 antibodies either from past infection or because they have been vaccinated, the latest survey from the Office for National... → https://is.gd/5505kW12:20
BrainstormUpdates for Finland: +683 cases (now 128544), +29478 tests (now 6.6 million) since 22 hours ago — Latvia: +340 cases (now 143446), +1 deaths (now 2580), +3105 vaccines (now 862179) since 23 hours ago — Brunei: +102 cases (now 2960), +1 deaths (now 12), +12468 vaccines (now 231613), +3857 tests (now 239143) since 22 hours ago [... want %more?]12:31
BrainstormNew from Pfizer: Anonymous: Pfizer Announces Start of Phase 3 Clinical Trial in Adults for Its Investigational Vaccine Against Respiratory Syncytial Virus (RSV) → https://is.gd/iHsYAQ12:52
BrainstormNew from BMJ: Why we need to make space for grief: The past 18 months have seen more than their share of human tragedy. Some four million people have died as a result of the covid-19 pandemic, and over 35 million have been bereaved. Grief is the... → https://is.gd/Cd0ZLt13:13
BrainstormNew from Virology.ws: Innately Immune: New data suggest that children are less susceptible to severe COVID-19 because they have a stronger innate immune response than adults. → https://is.gd/U43N6F13:24
BrainstormNew from The Indian Express: World: Abu Dhabi scraps mandatory quarantine rule for fully vaccinated travellers → https://is.gd/d6fGpg13:35
BrainstormNew from Politico: Coronavirus: Belgium’s king and queen in isolation after coronavirus case within royal family → https://is.gd/C755xw13:46
BrainstormNew from WebMD: Mistrust, Politics, and Vaccines: How We Got Here, How We Fix It: Some Americans reveal that their COVID-19 vaccine reluctance stems from an already skeptical worldview, with mixed messaging only heightening their suspicions. → https://is.gd/8fnTZI14:08
BrainstormUpdates for United States: +368274 cases (now 39.9 million), +3072 deaths (now 651770) since 22 hours ago — Romania: +1470 cases (now 1.1 million), +26 deaths (now 34617), +40677 tests (now 11.6 million) since a day ago — Belgium: +2842 cases (now 1.2 million), +2 deaths (now 25382) since a day ago [... want %more?]14:36
BrainstormNew from NPR: CDC Recommends That Unvaccinated People Don't Travel Over Labor Day Weekend: The Centers for Disease Control and Prevention has expressed concern about the further spread of the delta variant. Health officials have been concerned about holiday weekends during the pandemic. → https://is.gd/8hlyLI14:51
BrainstormNew from Derek Lowe: @Dereklowe: Some of the loudest anti-vaccine voices have a big overlap with the "stolen election" crowd. Who have a big overlap with the white nationalist crowd.And another thing they have in common is Russian money, being used just to stir things up. Thread: → https://is.gd/ZacBe115:47
BrainstormNew from The Indian Express: World: WHO says Covid variant of interest Mu may be more resistant to vaccines: All you need to know → https://is.gd/A56Ukh15:57
BrainstormUpdates for Serbia: +3524 cases (now 769803), +15 deaths (now 7322), +16134 tests (now 5.1 million) since 23 hours ago — Iraq: +6948 cases (now 1.9 million), +56 deaths (now 20934), +38974 tests (now 14.4 million) since 23 hours ago — Norway: +1594 cases (now 162481), +38916 tests (now 7.3 million) since 23 hours ago [... want %more?]16:03
BrainstormNew from Eric Topol: @EricTopol: 3 Southern states are newly leading the US pandemic and currently have more new cases/100,000 people than any country of the world → https://is.gd/upPw1916:08
BrainstormNew from The Indian Express (Health): Life-style: Oxford-AstraZeneca vaccine team receive ‘hero’ award at GQ Men of the Year 2021 → https://is.gd/w33qkJ16:41
BrainstormNew from Reddit (test): CoronaVirus_ITALIA: Il virologo Pregliasco minaccia di “picchiare” i “no-vax”: “Attenzione, sono cintura marrone di karate” → https://is.gd/2oQY5b16:53
BrainstormUpdates for Cuba: +6208 cases (now 665672), +87 deaths (now 5464), +57137 tests (now 8.0 million) since 23 hours ago — Bangladesh: +3436 cases (now 1.5 million), +88 deaths (now 26362) since a day ago — Germany: +18549 cases (now 4.0 million), +228 deaths (now 92775) since 23 hours ago [... want %more?]17:05
BrainstormNew from LitCovid: (news): Bayhealth, COVID-19 and Technology - Safely Discovering our New Normal. → https://is.gd/drkDVU17:15
LjLdid you see France's death graph http://offloop.net/covid19/?default=France&cumulative=no17:40
LjLsummer is over, we can unhide the naughties?17:40
BrainstormUpdates for United Kingdom: +37830 cases (now 6.9 million), +119 deaths (now 132920), +1093025 tests (now 272.0 million) since 15 hours ago — Azerbaijan: +3759 cases (now 432495), +45 deaths (now 5722), +17678 tests (now 4.5 million) since 23 hours ago — Myanmar: +3459 cases (now 406099), +110 deaths (now 15600), +35248 tests (now 3.7 million) since 23 hours ago [... want %more?]18:07
BrainstormNew from Derek Lowe: @statnews: RT by @Dereklowe: People who are fully vaccinated against Covid-19 appear to have a much lower likelihood of developing long Covid than unvaccinated people even when they contract the coronavirus. https://buff.ly/3gXhxXYhttps://is.gd/6WSnLO18:41
BrainstormUpdates for Moldova: +787 cases (now 268892), +5 deaths (now 6411), +7005 tests (now 1.6 million) since 23 hours ago — Spain: +9561 cases (now 4.9 million), +168 deaths (now 84640) since 23 hours ago — Italy: +6754 cases (now 4.6 million), +62 deaths (now 129352) since 23 hours ago [... want %more?]19:09
BrainstormNew from NPR: Sorry, Tom Cruise Fans — New 'Top Gun' And 'Mission Impossible' Movies Delayed Again: The blockbuster movies have been pushed back once again — Top Gun: Maverick is now scheduled to hit theaters in the spring and Mission: Impossible 7 won't be released until next September. → https://is.gd/oUZswK19:13
BrainstormNew from CIDRAP: News Scan for Sep 02, 2021: Baricitinib and COVID-19 mortality COVID vaccine and Guillain-Barre CWD in Wisconsin → https://is.gd/sZPZqD19:34
nixonixi missread that baricitinib mortality reduction another day (as it would have been just 5% reduction - as it really was much higher, 8% vs 13%, aka 38% and low p compared to placebo arm)19:46
nixonixso i didnt look at actual paper, just read some comments that it had highish side effects, and some alternatives would perhaps be better19:47
nixonixbut that result is huge, and its cumulative with dexamethasone19:47
nixonixlarge RCT needed asap (perhaps with alternatives with similar mechanism)19:48
nixonixstill didnt help much for getting in ventilator. maybe results are not as reliable as they look like then?19:53
nixonix"27.8% of baricitinib and 30.5% of placebo recipients had outcomes requiring ventilation or high-flow oxygen needs, or they died."19:54
nixonixunless many avoided it, and CPAP or something was enough19:56
nixonixdex seems to have around 36% reduction in mortality for those in ventilator, but only 18% for those needing extra oxygen (study feb 2021, no idea whats the best current estimate)20:08
nixonixso it depends a lot, what do you compare. its not a silver bullet, but dex and heparin and like are still the best for late symptoms. before possibly baricitinib or similar, but i still doubt that result, because its not new - why wouldnt they have noticed that type of huge effect before?20:10
BrainstormUpdates for Singapore: +191 cases (now 67991), +322 vaccines (now 4.6 million) since a day ago — Luxembourg: +77 cases (now 75981), +1104 vaccines (now 407669) since a day ago — Jersey: +26 cases (now 9376), +396 vaccines (now 76256) since a day ago — France: +17710 cases (now 6.8 million) since 22 hours ago20:11
nixonixhow about this: "So we immediately threw the kitchen sink at it. All kinds of meds. Monoclonal antibodies, ivermectin, Z-Pak, Prednisone, everything. And I also got an NAD drip and a vitamin drip, and I did that three days in a row20:11
archpcMmmm cattle dewormer20:12
archpcIdiots20:12
nixonixwhat do you mean?20:12
nixonix.title https://twitter.com/RyanMarino/status/143284137645933773720:12
Brainstormnixonix: From twitter.com: Ryan Marino (@RyanMarino): "“I’ve done my research”" | nitter20:12
nixonix.title https://www.mediaite.com/podcasts/joe-rogan-has-covid-took-a-ton-of-drugs-to-treat-it-we-threw-the-kitchen-sink-at-it/20:13
Brainstormnixonix: From www.mediaite.com: Joe Rogan Got Covid and 'Threw the Kitchen Sink at It'20:13
nixonixso he took corticosteroids for early symptoms. i wonder if it was some celebrity docs prescription, or his nutritionists idea20:18
nixonixNAD drip is those crazy nutritionists shit.  those mAbs might have helped though20:19
archpcnixonix, I’ve just heard so much about ivermectin it’s just, getting old already hahaha20:21
nixonixhe didnt tell bout his rona before he felt better, several days later. it may be just roid effect, lets see20:21
nixonixhe's not very old or fat, though. prob will be ok20:21
nixonixmy guess is, youve discussed here about it before i came back. maybe wondering if it really works or not (it doesnt)20:22
archpcMainly pastored on social media, from both sides, family, etc, you know what I mean20:23
nixonixat least theres no evidence, no mechanism. no more chances that it would work than any random drug, it looks like. yeah its not 100% proved it doesnt, but the same with most drugs20:23
nixonixheres a good analysis on ivm studies:20:25
nixonix.title https://twitter.com/GidMK/status/141263580770214298220:25
Brainstormnixonix: From twitter.com: Health Nerd (@GidMK): "Another day, another systematic review and meta-analysis of the same ivermectin research published This one is positive. I don't think it should be 1/n" | nitter20:25
* archpc groans20:25
LjLarchpc, just because it's being used idiotically by some people and bought in the cattle dewormer version doesn't mean it shouldn't be studied like many other drugs are being studied for COVID repurposing20:28
LjLit's almost like if there's a decent drug that might work, we wouldn't use it as long as it's being used by people who are nuts20:29
archpcAlright20:29
dTalalso, bleach is useful in a healthcare context20:29
nixonixthey cant every drug there is20:29
LjLnixonix, if you look at the amount of papers, they pretty much did20:30
nixonixand the best of those studies on ivm already show, theres very little chance it would be beneficial for rona20:30
dTalThe ivermectin thing is really out of control though20:30
dTalit's chloroquine round 220:30
dTalincidentally I remember us IRC folk were on top of chloroquine wayyy before the Trumpers20:31
nixonixthere is some new uk study on ivm coming. i wonder why they are doing it20:31
dTalbut when the Trumpers got ahold of it, suddenly it was an idiot flag20:31
* archpc wonders why 20:31
LjLat least they aren't burning witches20:31
nixonix.title https://www.reuters.com/world/uk/oxford-university-explores-anti-parasitic-drug-ivermectin-covid-19-treatment-2021-06-22/20:31
Brainstormnixonix: From www.reuters.com: Oxford University explores anti-parasitic drug ivermectin as COVID-19 treatment | Reuters20:31
dTalI bet these things have real consequences on the actual science20:31
dTal"You want to study *what*? What are you, a fascist?"20:32
archpc:|20:32
nixonixoh, it seems they have tested antibiotics for this virus too...20:32
pwr22LjL: Speak for yourself 🔥20:33
* archpc smokes crack to keep the wuhan wiggles at bay20:33
LjLi would not recommend that20:33
archpccan’t get infected if the virus can’t survive in there20:33
archpc/s20:33
LjLthough i've got to say, i know developing new antivirals is tricky, but i kind of wonder, if all the efforts spent in repurposing every drug known to man had been spent developing a new, specific, targeted antiviral...?20:34
nixonix.title https://endpts.com/covid-19-roundup-mesoblast-takes-another-hit-as-fda-demands-additional-trial-ahead-of-any-eua-review/20:35
pwr22LjL: Boris said the UK was going to be doing that but I've heard fuck all20:35
Brainstormnixonix: From endpts.com: Covid-19 roundup: Pfizer, Merck start late-stage trials for Covid-19 pills; Merck begins PhIII study on post-exposure treatment – Endpoints News20:35
pwr22He promised covid wonder drugs by christmas this year20:35
pwr22that will mean we don't even need vaccines20:36
pwr22He also told me he can spin straw into gold20:36
nixonix.title https://www.nytimes.com/2021/06/17/health/covid-pill-antiviral.html?action=click&module=RelatedLinks&pgtype=Article20:36
Brainstormnixonix: From www.nytimes.com: A Pill to Treat Covid-19? The U.S. Is Betting on It. - The New York Times20:36
archpcAnyone in here get covid and have sudden horrible insomnia?20:37
nixonixits a main protease inhibitor (which cuts its polyprotein). those have been studied a lot, but nothing efficient has been found, unless those big pharmas are onto something20:40
dTalarchpc: that sucks man. Not heard of that one20:41
nixonixusually they havent been effective enough, so they should prob be used as a cocktail with some other mpro inhibitor20:41
nixonixand maybe some other type of antiviral, moab or like20:41
archpcdTal, some quick googling shows that it’s a common “long covid” affects20:42
dTalYou might try supplementing melatonin or 5-HTP20:42
archpceffect * (?)20:42
nixonixbut the problem is with moabs, they are expensive and not pills, would be needed for early symptoms, preferably used in home20:42
LjL%title https://www.nytimes.com/2021/06/17/health/covid-pill-antiviral.html testing20:42
archpcI’ve tried melatonin, nothing, hadn’t tried HTP20:42
LjLmelatonin just gives me nightmares20:43
LjL%title https://www.nytimes.com/2021/06/17/health/covid-pill-antiviral.html testing20:43
nixonixi doubt us 3.2B program finds anything, more likely its some big pharma stacking 2-3 their own products, and selling it for good price20:43
dTal5-HTP is legit, it has a number of effects but improved sleep is one - I think it metabolizes into mekatonin eventually20:44
LjL.title https://www.nytimes.com/2021/06/17/health/covid-pill-antiviral.html testing20:44
dTalanother effect is improved sleep / decreased need for sleep20:44
nixonix.title20:44
LjLbleh turns out " doesn't comment out lines as well as #20:44
dTal*improved sleep quality20:44
nixonixmelatonin didnt work for me, tried multiple times with 1-5mg. nothing happened, noticed no difference. not placebo prone20:45
pwr225-HTP is serotonin / a precursor I think?20:47
LjLAs of 25 August 2020, Hungary added 5-HTP to the controlled psychoactive substances list, prohibiting production, sale, import, storage and use, becoming first country to do so.[51]20:47
LjLalways so progressive20:48
dTalyes, and serotonin is a melatonin precursor20:48
LjLbut also: Potential side effects of 5-HTP include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, vivid dreams or nightmares, and muscle problems.[21]20:48
LjLgiven the vivid dreams or nightmares from melatonin... no thanks20:48
nixonix.title https://www.news-medical.net/news/20210825/Brain-refreshing-takes-place-during-the-dream-active-phase-of-sleep.aspx20:49
archpcI’ll take those side effects just please let me have more than an hour of sleep20:49
Brainstormnixonix: From www.news-medical.net: Brain refreshing takes place during the dream-active phase of sleep20:49
dTalThere's also cannabis20:50
pwr22dTal: ah interesting didn't know that. Does having more serotonin or its precursor available actually increase production of melotonin though if you aren't deficient / depleted in those things already20:50
pwr22* things already?20:50
pwr22I keep confusing melatonin with melanin too 🤦‍♂️20:50
pwr22been doing that for years20:50
dTalpwr22, I really don't know how the pathways work. Anecdotally I can say that 5-HTP at bedtime makes a very perceptible difference in how I feel the next morning, but tolerance builds rapidly20:51
dTalPresumably production of... something... downregulates to compensate for the supplement20:52
archpcdTal, cannabis and my brain dint20:53
archpcDont mix well *20:53
pwr22dTal: ah interesting20:55
nixonix.title https://twitter.com/loriricespring/status/143176945268156825920:58
Brainstormnixonix: From twitter.com: Lori Rice-Spring (@loriricespring): "My son listens to Joe Rogan and refuses to get a vaccine. He’s responsible for millions of young men not getting the vaccine." | El Pajarito de NoGAFAM20:58
nixonixthen there was that twitter pic, listing groups like us congress (almost 100% vaxed, reps and dems alike), us physicians (way less, 8x% i think! lots of loonies among them)20:59
specinglots of physicians probably got it and have natural immunity now21:00
specingand will get boosters once the time comes21:00
nixonixso they are using people's health and lives for their own benefit. they get vaccinated, but what they talk to people, is more or less antivax or rona denialist shit. not all, but many21:00
nixonixwhen it seems not everybody got IgG response (may still have protection, but not certain), id get the fist dose maybe 2 months from infection, and the 2nd 3 months after that. but that lack of IgG for many need still confirmation21:04
nixonixboosters... 2 weeks ago a well known finnish virologists said in interview, that 3rd dose is probably needed after 2-3 years21:05
nixonixthat time there was already enough information available, that it wanes way faster. circulating abs reducing infection probability and transmission. probably protection too, just slower21:06
nixonixthe same virologist said in summer 2020, that he thinks the 2nd wave wont hit finland in the fall21:08
nixonixi checked, he said that if the suppressing works during the summer (2000), the 2nd wave may never come in significant numbers21:10
nixonixanyone want to swap hc officials and experts?21:10
nixonixyoull get 3 for 121:11
specinghttps://en.wikipedia.org/wiki/1972_Yugoslav_smallpox_outbreak21:16
imaginarynixonix: do you have a link to that twitter image that showed US congress vaccination rates?21:16
nixonixno, i lost it and asked here yesterday, if anyone remembers if i pasted the link here. if i find it, ill put it here21:16
nixonixi didnt confirm the numbers though21:16
nixonixi found an older article saying many of the house reps didnt answer in survey. so if the percentages were correct in the pic, it might have been just those that had answered21:18
BrainstormNew from WebMD: (news): Human Trials for HIV Vaccine Created With mRNA Technology to Begin → https://is.gd/RnUYyJ21:21
nixonixCNN has sent multiple inquiries to members of Congress and reviewed public statements but is unable to confirm the vaccination status of almost half the Republican conference21:23
nixonixthe pic said "congress", not house or senate (but cant be sure if the numbers were correct or not, tho. if were, prob only for those that had answered)21:24
nixonixid assume most if not all those not answering, have been vaxed. imo21:24
imaginarysame21:24
imaginaryi'm finding ab unch of stuff on house representatives as well tho, not congress21:25
imaginaryweird21:25
imaginarysurely such a picture isn't hard to find but i can't seem to find it21:25
nixonixIn the Republican Senate conference, ​46 of 50 senators confirmed to CNN that they are vaccinated. Only two refuse to say if they are not vaccinated21:25
nixonixbut over 5 weeks old article21:25
nixonixso they are using people. let them get organ damage or die, while protecting themself. in this case its reps because theres a political division that way in usa, but i dont doubt similarly only their own ass interest dems, or other politicians21:28
nixonixirene tossetti said, there's always free ICU bed for VIPs21:28
nixonixyet, excluding loonies like rogan, they still vax their ass...21:29
nixonix.title https://www.ama-assn.org/press-center/press-releases/ama-survey-shows-over-96-doctors-fully-vaccinated-against-covid-19  maybe i remembered the percentage for physicians wrong, or another survey. this was on june21:35
Brainstormnixonix: From www.ama-assn.org: AMA survey shows over 96% of doctors fully vaccinated against COVID-19 | American Medical Association21:35
nixonixand additional 45% planned to be vaxed. making 98%21:35
nixonixthat makes more sense21:35
imaginaryskimmed through the logs and couldn't find a link to the image for the congress numbers21:37
imaginarymaybe it just wasn't shared here21:37
nixonixit is in my url history, but pictures and memes and like often dont have descriptive text, making finding very hard21:39
de-facto.title https://www.who.int/news/item/01-09-2021-who-germany-open-hub-for-pandemic-and-epidemic-intelligence-in-berlin21:43
Brainstormde-facto: From www.who.int: WHO, Germany open Hub for Pandemic and Epidemic Intelligence in Berlin21:43
nixonixfound! i think it was this one, or then i saw the same as a pic too:21:44
nixonix.title https://twitter.com/LaurelCoons/status/143163191358063001921:44
Brainstormnixonix: From twitter.com: Laurel Coons 🧬🧬🧬 (@LaurelCoons): "Who Is Vaccinated: 💉100% of living US presidents 💉Almost 100% of US Congress 💉100% of US governors 💉100% of US military by mid-Sep 💉96% of practicing US physicians [...]21:44
nixonix.title https://twitter.com/paulcogan/status/1430947279301746697 - this one looks more like the one i saw before, though21:45
Brainstormnixonix: From twitter.com: Paul Cogan (@PaulCogan): "Who’s vaccinated? 1. Donald Trump and every other living US president 2. All 50 governors- both R and D 3. Nearly 100% of US Congress 4. 96% of American physicians 5. 75-80% [...]21:45
nixonixit really bugs me if i dont remember or find something. so usually i dont give up. this time i cheated with google jitsu21:52
twomoonhi nixo21:52
twomoonthis is why zotero exists21:52
nixonixfor some reason ljl doesnt save all my links or wisdoms there. oh, i had some daily mail article i planned to share...21:54
BrainstormNew from WebMD: Teachers Have No Higher Risk of Severe COVID-19: A new report finds teachers have no greater risk of catching or being hospitalized for severe COVID-19 than anyone else. → https://is.gd/DPRadX21:54
twomoonmaybe i need to copy paste your wise words somewhere21:54
twomoonbut i'm lazy21:54
twomoonbut indeed it is valuable information21:54
twomoonbut i don't think you would want someone copying your chats all the time21:55
BrainstormUpdates for Kenya: +970 cases (now 237851), +7 deaths (now 4746), +7940 tests (now 2.4 million) since 21 hours ago — Togo: +224 cases (now 21785), +2 deaths (now 187), +2269 tests (now 466510) since a day ago22:05
nixonixinstead of just pcr (which can show up also unviable fragments), cell culture comparisons of nasal swab and saliva:22:12
nixonix.title https://www.medrxiv.org/content/10.1101/2021.08.30.21262701v122:12
Brainstormnixonix: From www.medrxiv.org: Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution | medRxiv22:12
LjLpre-delta22:16
archpcI have gotten my government mandated hour of sleep22:20
nixonixyeah, but probably reduces a lot delta shedding too. looks way better than that pcr cycle comparison, which found similar cycles for the first 6 days22:21
nixonixneeds larger study22:23
nixonixas i thought about those 6 days similar cyles results: "Regardless, these data further illustrate that Ct/Cn values cannot be used as a simple surrogate for infectious potential"22:24
nixonixanother very good news. with that baricitinib22:26
imaginarynixonix: ah nice you found it. i wonder what their sources are tho22:29
nixonix.title https://twitter.com/drmenonsunil9/status/1433296289131745285  ive heard something about this before, but not familiar with the subject. apparently different probs from platelet serotonin depletion22:30
Brainstormnixonix: From twitter.com: Dr Sunil Menon (@drmenonsunil9): "https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3800402 This hypothesis by Dr Farid Jallali would be worth looking into. Explains how high levels of serotonin [...]22:30
nixonixyeah, prob including only those that responed, for congress. senate and ama physician results confirmed, and i read about army too22:31
nixonix.title https://twitter.com/EricTopol/status/1433474136332931077  for the pic from the study above, although it has good information, the actual paper22:33
Brainstormnixonix: From twitter.com: Eric Topol (@EricTopol): "A unique, high resolution study of 23 breakthrough infections (pre-Delta) shows how vaccination reduces transmission, leads to less virus culture positivity, for less days, [...]22:33
nixonix.title https://twitter.com/EricTopol/status/1433465783162601480  no women in irc, but maybe somebody knows a woman22:34
Brainstormnixonix: From twitter.com: Eric Topol (@EricTopol): "A systematic review of #AI for mammography is very disappointing "Thirty four (94%) of 36 AI systems evaluated in these studies were less accurate than a single radiologist, [...]22:34
BrainstormNew from Eric Topol: @EricTopol: Many countries have gotten > 95% of people over age 65 fully vaccinated. The US is at 82%, which is leaving many vulnerable in this high-risk group. @paula_span is on ithttps://www.nytimes.com/2021/09/02/health/covid-vaccines-seniors.html(no less the immunity waning in the 1st group vaccinated > 6 months ago) → https://is.gd/touOIP22:37
nixonix.title https://ourworldindata.org/grapher/covid-vaccine-willingness-and-people-vaccinated-by-country?time=2021-08-15&country=CAN~DNK~FRA~DEU~ITA~NOR~KOR~GBR~USA~AUS~FIN~JPN~ESP~SWE~SGP~NLD22:41
Brainstormnixonix: From ourworldindata.org: Willingness to get vaccinated against COVID-19 - Our World in Data22:41
nixonixnot believable for uk22:41
pwr22It's from yougov so I guess that's what yougov people think22:43
nixonixquote of the day: "Over the course of a viral infection, a tremendous number of virions are produced: up to 1014—more than there are stars in the Milky Way"22:44
nixonix10^1422:44
pwr22😀22:44
nixonixhundreds of thousands per cell22:44
pwr22More than 1014 you say22:44
nixonixi just tested first how it translates the exponent, suspecting problems22:45
BrainstormNew from CIDRAP: Study: Vaccines slash long-haul COVID, hospital rates: Mary Van Beusekom | News Writer | CIDRAP News Sep 02, 2021 The odds of long COVID-19 fall by more than half after two doses of vaccine. → https://is.gd/eDbR7a22:47
specingjust more than half? Thats disappointing22:53
BrainstormNew from r/WorldNews: worldnews: Italy may eventually make COVID vaccine shots compulsory for all, Draghi says → https://is.gd/Kpgkxz22:58
rpifantoday i got my positive pcr test officially recognized23:01
rpifannow i have only february 2022 before i need to get a shot23:02
rpifani really hope novavax is ready by then23:02
nixonixgot rid of symptoms?23:05
nixonixgood thing that german hub. i was just thinking that when finnish hc officials and other experts dont seem to have time to read the new research, they apparently get majority of their information from uk hc officials. and how much they have time to serve some little countries needs23:10
nixonixthey should have team that keeps up with the research, then gives summaries of the important stuff to other officials. i just read on hc official wished she had more time to read new papers, other than in the evenings and weekends23:12
twomoonwhy don't you go work for the finnish gov?23:12
nixonix.title https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783685  moderna stronger again23:18
Brainstormnixonix: From jamanetwork.com: Comparison of SARS-CoV-2 Antibody Response by Age Among Recipients of the BNT162b2 vs the mRNA-1273 Vaccine | Infectious Diseases | JAMA Network Open | JAMA Network23:18
nixonixhttps://twitter.com/talepani/status/141393263514404045523:25
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Comparison of SARS-CoV-2 Antibody Response by Age Among Recipients of the BNT162b2 vs the mRNA-1273 Vaccine ( https://www.zotero.org/groups/covid_links/items/7V98XFJH )23:27
BrainstormUpdates for Jamaica: +572 cases (now 69054), +19 deaths (now 1568), +1685 tests (now 550980) since a day ago — Wallis and Futuna, France: +9 cases (now 454) since 19 days ago — Mali: +14 cases (now 14909), +1282 tests (now 385369) since a day ago — France: +12711 cases (now 6.8 million) since 20 hours ago23:32
LjLi don't know why Draghi feels the need to say that we "may" make the vaccine mandatory later23:40
LjLjust to make people angry in advance?23:40
LjLwe already had the health secretary or whoever it was being like "i'm sure we'll reach 80% by the end of september. if not, we may make it mandatory"23:41
LjLso it's going to be optional as long as everybody gets it23:41
BrainstormNew from Eric Topol: @EricTopol: Portugal is ~25 per cent points above the US in % fully vaccinated people, and one of top few of the world.Look at how it has handled Delta vs the US. → https://is.gd/pZoBIy23:41
LjLThe Atlantic doesn't seem too happy with Australia's COVID restrictions https://www.theatlantic.com/ideas/archive/2021/09/pandemic-australia-still-liberal-democracy/619940/ and to be fair that quarantine app seems creepy although the article should make it clearer it's only for people under quarantine23:55
LjLhttps://www.abc.net.au/news/2021-08-23/how-will-south-australias-home-quarantine-trial-work/100398878 explains better23:56

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