libera/##covid-19/ Saturday, 2021-10-16

BrainstormUpdates for Bahrain: +63 cases (now 275975), +15085 tests (now 6.7 million) since a day ago00:09
BrainstormNew from r/Science: science: News avoidance during the COVID-19 pandemic is associated with better mental well-being β†’ https://is.gd/e4LWaG00:15
BrainstormUpdates for Germany: +11656 cases (now 4.4 million), +82 deaths (now 95416) since 23 hours ago β€” Bulgaria: +3440 cases (now 537752), +86 deaths (now 22188), +24724 tests (now 5.1 million) since a day ago β€” Moldova: +1407 cases (now 313849), +35 deaths (now 7172), +16172 tests (now 1.9 million) since a day ago [... want %more?]00:34
BrainstormNew from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): Just to make clear the scientific contradictions in today's VRBPAC vote, which recommended J&J boosters for #JnJers but not yet Moderna or Pfizer boosters: pic.twitter.com/FF4uykZOcj β†’ https://is.gd/BB43fE00:47
LjL%wik VRBPAC00:55
BrainstormLjL, from English Wikipedia: The Center for Biologics Evaluation and Research (CBER) is one of six main centers for the U.S. Food and Drug Administration (FDA), which is a part of the U.S. Department of Health and Human Services. The current Director of CBER is Peter Marks, M.D., PhD. CBER is [... want %more?] β†’ https://en.wikipedia.org/wiki/Center_for_Biologics_Evaluation_and_Research00:55
LjLwell i guess it's not so much a scientific thing sadly, but a legal thing00:56
LjLJ&J can endorse J&J boosters00:56
LjLif it's not "made for J&J" i assume there would be a wholly different procedure for approving it00:57
BrainstormUpdates for Colombia: +1646 cases (now 5.0 million), +37 deaths (now 126796), +45480 tests (now 26.2 million) since 23 hours ago β€” Argentina: +1358 cases (now 5.3 million), +27 deaths (now 115660), +44729 tests (now 24.4 million) since 23 hours ago00:59
BrainstormNew from r/WorldNews: worldnews: Iqaluit hospital limits surgeries as city water tests show 'exceedingly high concentrations' of fuel β†’ https://is.gd/lLHCAm01:08
LjLuff01:15
LjLnot sure if this was posted by the bot but just sharing myserynews01:15
LjL%title https://twitter.com/fitterhappierAJ/status/144898124909216972801:15
BrainstormLjL: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "Yes. Cov2 beats adaptive memory. I have said it many times (and am attacked for it)." | 42l - nitter01:16
LjLand also bots that don't work01:16
LjL"Florian Krammer on TWIV: Memory B cells take 4-7 days to respond to infection. Delta may be fast enough (in replication) to outrun that."01:16
LjLif so then we'll always need antibodies circulating, i guess? which means even a delta-specific vaccine would need very frequent boosters?01:16
de-factowell Delta will mutate and get selected for maximizing fitness under the majority conditions, e.g. become even more fit even in vaccinated01:21
LjLnot if we have vaccines providing sterile immunity01:24
de-factowell we surely have no sterilizing immunity in any population worldwide01:24
de-factoand quite a lot of incidence for breeding going on01:24
LjLthat's clear01:24
LjLbut i'm talking about delta-specific vaccines01:25
LjLwithout them, we'll never get much of anywhere01:25
LjL*with* them, we may still need boosters too frequently for feasibility/comfort, if the above is accurate01:25
LjLnow sure how worse it can get, although i have learned to assume "a lot"01:25
de-factoit all depends on antigenic drift01:26
LjLbut afaik any vaccine will eventually have antibodies wane01:26
de-factomaybe we still have some time, but eventually it will become more aggressive because it selects for fitness01:26
LjLi'm honestly starting to understand people who think the vaccines are a joke. i also understand how they aren't, but it all went pretty wrong01:28
de-factothe vaccines work much better than we could have hoped for in 202001:28
LjLcome on, these were touted as some of the most effective vaccines in history01:28
de-factoyet it was clear they wond solve the problem on their own01:28
LjLwell it might have been clear to you, but it wasn't the message being given to people01:29
LjLto be fair, yes, you always did say they weren't enough01:29
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): The scientific consensus seems obsessed with the superior antibodies that may accompany the combo. They may be right. But in 10 years I think we'll find that proteins outside Spike are conferring T cell-mediated immunity. β†’ https://is.gd/uTWQmN01:29
LjLbut your megaphone probably doesn't extend much farther than this channel01:29
de-factoi think it was clear to everyone that thinks about spread of the phylogenetic tree and selection of the fittest01:30
de-factoits all about timing and so far the pathogen was faster than us01:31
LjLmost people can't spell "phylogenetic tree". so yes, maybe it was, but that still means like 0.1% of people01:32
de-factoin my personal opinion we are not trying hard enough01:35
de-factowhere are the updates for the VoCs? not available after 2 years01:35
de-factowhere are the intranasal vaccines01:35
de-factohell we did not even deliver the ones we got to every country in sufficient quantities01:36
LjLwell in my own opinion that just reinforces what i've said: most people, including policymakers, have focused on vaccines as *the* way to beat this, and since we got vaccines that seemed to darned effective, all the other things were de-prioritized01:36
BrainstormUpdates for Bolivia: +542 cases (now 505699), +7 deaths (now 18818), +6755 tests (now 2.5 million) since a day ago β€” Uruguay: +187 cases (now 390762), +1 deaths (now 6066), +18648 tests (now 3.7 million) since a day ago β€” Paraguay: +21 cases (now 460322), +1 deaths (now 16209), +1760 tests (now 1.9 million) since a day ago β€” Netherlands: +3745 cases (now 2.1 million) since 23 hours ago01:36
de-factoyes of course01:36
LjLs/to/so/01:36
de-factoit would have been a "cheap" way to profit and praise themselves with having solved the pandemic with "their" vaccine campaign, yet of course reality is more complex01:37
de-factoi mean we are not doing too bad either, but imho we could have done better01:38
LjLsome people would call that sentence above anti-vax already, and i think that's a problem, the usual extreme polarization problem01:39
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Novavax Announces COVID-19 Vaccine Booster Data Demonstrating Four-Fold Increase in Neutralizing Antibody Levels Versus Peak Responses After Primary Vaccination - Aug 5, 2021 ( https://www.zotero.org/groups/covid_links/items/552R49SH )01:39
de-factowe could have taken the hint and install a global testing and screening platform, provide reliable and cheap PCR tests for everyone01:39
de-factohaving such a global capability would mean we would have gained the ability to track and isolate also other future outbreaks with other pathogens01:40
de-factoalso we could have installed a platform for decentralized and fast delivery of mRNA vaccines that could be printed "on demand" and download their updates from a central server that distributes updates in realtime01:41
de-factowe could have investigated ways to predict antigenic drift under given selection pressure01:41
LjLugggh, Novavax changing the URLs to their press releases01:43
de-factowe could have investigated new ways for vaccination for respiratory diseases such as intranasal vaccines01:43
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Novavax Investor Relations - Press Releases & Statements ( https://www.zotero.org/groups/covid_links/items/XQEHAS6G )01:44
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Preliminary Efficacy of the NVX-CoV2373 Covid-19 Vaccine Against the B.1.351 Variant ( https://www.zotero.org/groups/covid_links/items/CWDM2HMV )01:44
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Novavax Investor Relations - Press Releases & Statements ( https://www.zotero.org/groups/covid_links/items/P6NBJ8X5 )01:44
de-factowe already could have experience with that by now, we could know how long protection lasts etc01:44
de-factowe could predict a time window in which we would have to reach the majority of population for sterilizing immunity by intranasal vaccinations in order to get rid of the problem01:45
de-factoinstead we assume its "impossible" and dont even try01:45
de-factoit is possible of course, in fact we just dont know how hard it really would be in reality01:46
de-factowe already have been on a good way with our efforts, it just was not enough yet01:46
de-facto.title https://www.nature.com/articles/s41579-021-00642-401:46
Brainstormde-facto: From www.nature.com: Influenza lineage extinction during the COVID-19 pandemic? | Nature Reviews Microbiology01:46
de-factowe could have thought about ways to prevent global spread by airtravel industry, yet we dont even tried out approaches01:48
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Novavax COVID-19 Vaccine Demonstrates 90% Overall Efficacy and 100% Protection Against Moderate and Severe Disease in PREVENT-19 Phase 3 Trial - Jun 14, 2021 ( https://www.zotero.org/groups/covid_links/items/JNIMK3SU )01:49
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Novavax COVID-19 Vaccine Demonstrates 89.3% Efficacy in UK Phase 3 Trial ( https://www.zotero.org/groups/covid_links/items/VTVG9RRS )01:49
de-factoits just alibi things such as "quicktest" to address those that see the problems with it, basically saying "leave us alone, we dont care about implementing proper biosecurity"01:49
de-factoto be honest i am not really surprised about the outcome: variants still spread all over the globe in a few days to weeks01:50
LjLwhat's the influenza thing supposed to hint at though? should we have had lockdowns indefinitely until all influenza B is eradicated, even without covid?01:50
BrainstormNew from https://covid19.specops.network : Update the URLs for Novavax press releases: Nice going changing URLs to things that people want to refer to for a long time, cool! β†’ https://is.gd/zStZ3301:50
de-factoit was the hint that global efforts have global effects, not indefinitely but synchronized01:51
de-factobut i guess some people are just not ready to live in a global world that tries to base their decisions on empiric sciences if scientists that speak out publicly are threatened for doing so01:54
de-facto.title https://www.nature.com/articles/d41586-021-02741-x01:56
Brainstormde-facto: From www.nature.com: β€˜I hope you die’: how the COVID pandemic unleashed attacks on scientists01:56
LjLwhat about "She called the police, but didn’t hear that they took any action. The threatening e-mails, calls and online comments continued. The police officer who visited Kuppalli after a second death-threat call suggested she should get herself a gun."01:57
LjLnot sure the problem here is just angry people01:57
LjLpeople express anger in irrational and even criminal ways, that's not justified but also not surprising i think. our society is just showing cracks all over the place, and when police tells you "defend yourself" that's one crack01:58
de-factothe problem is that people get emotional instead of rational01:59
de-factoi think people are just not ready to deal with such problems01:59
LjLwe're designed to get emotional when it comes to risking death02:00
de-factomany think only about their own feelings, not about what way of behavior would be most rational in favor of the interest of majorities02:00
LjLthat may not work very well in the present situation, but i'm not sure we can change the way our brains are wired at a fingersnap02:00
BrainstormNew from https://covid19.specops.network : ljl-covid: Add Novavax press release about 3rd booster dose β†’ https://is.gd/QXsgsv02:01
LjLthere should be policymakers and bodies developed over many years to create a "rational superstructure" if you wish02:01
de-factoi think in that regard the pandemic revealed that maybe we are not nearly as developed as we wished we were02:01
LjLbut they've failed, they're no better than the individuals, they collectively have acted emotionally too02:01
BrainstormUpdates for Nigeria: +167 cases (now 208797), +2 deaths (now 2769), +52857 tests (now 3.1 million) since 12 hours ago β€” Ivory Coast: +40 cases (now 60982), +1 deaths (now 674), +10952 tests (now 1.1 million) since 23 hours ago02:01
LjL(or failed to act)02:01
de-factofor my taste priorities were not chosen for containment right form begin, every individual, nation, organization, company, younameit, put themselves first02:02
LjLhttps://twitter.com/Sars2_Club/status/1449077094865121283 this says "M.D." and yet see where they put the "basing things on science"02:05
de-factook maybe thats not fair, many also put a lot of effort into containing it, lets say too many did not put containment before their own evasion of blame or possibility for profit02:06
de-factoi think our technological development went ahead of our mental capacities, most are just not ready for a globalized world02:16
LjLi know i'm not the kind of person who'd survive a societal collapse02:26
LjLso whoever is, say hi to the world to come for me i guess02:27
de-factoin my opinion its completely fine to make mistakes, what bugs me is when people dont act according to their best knowledge, e.g. learn from mistakes instead of repeating them02:32
de-factowe need to close feedback loops that bring us forward into the direction of interest of majorities02:35
LjLhow02:35
de-factoat the start of the pandemic there was that collaborative spirit that really gave some kind of hope that we may all work together instead of against each others02:36
LjLi found it fake and annoying from the start02:37
de-factowe somehow have to overcome that polarization that divides us into distinct groups that may not even understand each others at some point anymore02:37
LjL"andrΓ  tutto bene", sure, totally02:37
de-factoi dont know how we can achieve that, but in my opinion its the origin of many problems we are dealing with right now, the lack of collaboration and cohesion in our society02:38
BrainstormUpdates for United Kingdom: +44336 cases (now 8.4 million) since 21 hours ago β€” Curacao: +14 cases (now 16899), +2 deaths (now 171), +1621 tests (now 295861) since a day ago β€” India: +163 deaths (now 452010) since 19 hours ago02:38
de-factowhen i say "absolutely strictly without exception" what i really mean is that i desperately wish for more cohesion and coherence in our strategy02:40
LjLwell i don't have much advice on how to get that, but my first and foremost bit is: don't oversell02:41
LjLif vaccines are probably cool but they aren't "99% of the hospitalized are unvaccinated", then don't say that02:41
LjLyou say that, you disappoint people when they find it's not true or it's a misrepresentation of truth, you get more anti-vax02:41
LjLnot you, i know you never said that02:42
LjLbut it's media "memes" that make the rounds in the news on and on, at least that particular one did in the US, and other unrealistic ones did elsewheree02:42
de-factoyes you got a point there, trust is essential for a coherent strategy that originates from within everyones heads and thoughts, its not about sticking to some rules or such, its about agreeing on what makes sense in terms of working together02:43
LjLand if Scandinavia says that they aren't sure the vaccines' benefits outweigh the risks for people who are 25 or whatever, then maybe they're right, maybe let's not oversell it. the "it's a risk/benefit thing" refrain sometimes sounds like it's only valid when the benefits outweigh the risks but becomes invalid when it's the other way around, which is silly02:43
LjLconspiracy time https://twitter.com/__philipn__/status/144095367812745625602:59
LjL(and by "conspiracy" i mean "i find it obvious it's overwhelmingly likely to have been a lab leak, but i wonder if anyone is on the ball as to how it took place exactly")03:01
BrainstormUpdates for Channel Islands: +39 cases (now 12174), +9031 tests (now 973750) since a day ago β€” Guinea-Bissau: +5 cases (now 6129), +273 tests (now 100498) since 23 hours ago03:03
BrainstormNew from r/WorldNews: worldnews: Brazil pandemic probe to recommend Bolsonaro face 11 criminal charges, senator says β†’ https://is.gd/yth6cl03:14
ublxsemms odd that google doesn't have a whole lot to say about 'project defuse'03:34
ublxwas expecting mainstream clamouring for validation of documents made available by 'anonymous source'03:35
ublx*seems03:35
BrainstormUpdates for Barbados: +322 cases (now 12427), +1 deaths (now 109), +2724 tests (now 352994) since a day ago β€” Malawi: +7 cases (now 61709), +909 tests (now 417798) since a day ago03:41
BrainstormNew from Reddit (test): Covid2019: 90,000 U.S. adult deaths from COVID-19 over the summer could have been prevented if victims had been vaccinated, study finds β†’ https://is.gd/M5v7SB03:45
BrainstormNew from NPR: The CDC emphasizes COVID vaccinations as a key to safe holiday gatherings: The CDC says that having every person in attendance vaccinated is important for protecting those who can't get a shot. And it recommends that those who aren't fully vaccinated delay travel. β†’ https://is.gd/q1Xud104:07
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Our covid times :-(by @MatttDavies pic.twitter.com/lccv6ocZtf β†’ https://is.gd/4F9Pkg04:17
BrainstormUpdates for South Korea: +1617 cases (now 340978), +18 deaths (now 2644), +45666 tests (now 15.2 million) since 23 hours ago β€” Bolivia: +451 cases (now 506150), +6 deaths (now 18824), +6007 tests (now 2.5 million) since 2 hours ago β€” St. Vin. and Gren.: +201 cases (now 4418), +5 deaths (now 47) since a day ago [... want %more?]04:30
BrainstormNew from r/WorldNews: worldnews: Brazil pandemic probe to recommend Bolsonaro face 11 criminal charges, senator says β†’ https://is.gd/Bi9MK104:59
sdfgsdfgsso if myocarditis risk is about 2-3% does that mean it actually affects everyone but we can only observe the effects on 3% of people05:18
sdfgsdfgsso the vaccines enlarge everyones heart and weakens their heart muscle ?05:19
BrainstormNew from The Indian Express: World: Second J&J COVID-19 shot gets expert backing; FDA is looking at lowering age for Pfizer booster β†’ https://is.gd/ZblaZM05:20
BrainstormUpdates for Belgium: +3648 cases (now 1.3 million), +15 deaths (now 25747) since a day ago β€” Pakistan: +893 cases (now 1.3 million), +24 deaths (now 28252), +52589 tests (now 20.2 million) since a day ago05:32
de-factoi dont think that is the case, the myocarditis is a *very* rare side effect that affects very few young men in first week after second mRNA dose05:38
de-factonot nearly anything in the percent range or such05:38
de-factoand afaik the very majority of those very rare myocarditis cases recover fully05:38
de-factoso it does not make any sense to assume it affects everyone05:39
sdfgsdfgswho ever gets EKG after vaccine ?05:39
ublx0.001% might be a more reasonable ballpark05:39
sdfgsdfgsdetection of myocarditis is not easy05:40
de-factothey had that on the radar because it happens much more often in COVID cases05:40
de-factomany athletes that catched covid were diagnosed with temporary myocarditis05:41
BrainstormNew from COVID tweets: Prof Francois Balloux (@BallouxFrancois): A222V was found in the B.1.177 lineage that swept Europe in the summer of 2020, but careful follow-up analyses pointed to the lineage likely having no inherent transmissibility advantage and that its spread was caused by demographic processes.6/nature.com/articles/s4158… β†’ https://is.gd/GT00Eq05:41
de-facto.title https://jamanetwork.com/journals/jamacardiology/fullarticle/278054805:44
Brainstormde-facto: From jamanetwork.com: Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection: Results From the Big Ten COVID-19 Cardiac Registry | Cardiology | JAMA Cardiology | JAMA Network05:44
de-facto.title https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/278480005:47
Brainstormde-facto: From jamanetwork.com: Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older | Cardiology | JAMA Internal Medicine | JAMA Network05:47
de-factoso its percent (covid) vs parts-per-million (mRNA)05:47
de-factoand also restricted to young men05:47
de-factoso its completely crazy to assume it would affect everyone05:48
de-factothe (very rare) risk from vaccination probably can be lowered even more by insisting on aspiration and avoid high-pulse scenarios for 1-2 weeks after receiving the shot05:50
de-factoboth things i keep repeating like a broken record since the vaccinations began05:51
ublxinteresting numbers in here: https://www.heartlungcirc.org/article/S1443-9506(21)01156-2/fulltext05:51
ublx"Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination"05:51
ublx"The US Centers for Disease Control and Prevention (CDC) by mid-June 2021 had reported 1,226 cases of myocarditis after mRNA vaccination (Pfizer or Moderna, 29 December 2020–11 June 2021) from 296 million doses"05:52
BrainstormNew from The Indian Express: World: US will accept mixed doses of vaccines from international travelers β†’ https://is.gd/7FJbmp05:52
ublxso about 0.0004%05:52
sdfgsdfgslike I said, EKG would only be done on hospitalized covid cases05:53
sdfgsdfgsthere's no myocarditis detection after vaccine, we wouldn't know05:53
sdfgsdfgshow do we even know ?05:53
sdfgsdfgsI'm confused05:53
sdfgsdfgson large scale it could be affecting many more people05:54
sdfgsdfgsweird05:55
de-factoso if it does not affect many more people it means most (the very majority) does not have such problems with it05:56
de-factoyet still, why not go and chill for a week after the shot to make sure there is no such risk, even when its super rare?05:56
ublxthat is an interesting thought, the supposition that young men are least likely to go and chill05:57
de-factobtw afaik it was known before already that its the young men that also are most likely to get myocarditis from other (respiratory?) viral infections06:02
de-factoso there is something about young men that elevates the risk for them in general06:02
de-factoyet afaik they do recover from such conditions by themselves06:04
de-factoi mean what do they even do when hospitalized as a precaution? ensure they rest and chill?06:04
ublx"Consequently, CDC physicians and cardiologists evaluated 484 cases of patients aged under 30 years, with 323 individuals that strictly met definitions as per Dallas Criteria and Lake Louise Criteria for acute myocarditis ...06:05
ublx... Of note is that 96% of these individuals were promptly hospitalised. Most patients were managed through mild clinical courses that resolved, with subsequent hospital discharge; there were no deaths."06:05
ublxpresumably mild inflammation going unnoticed resolves with even less drama06:07
de-factoyeah or maybe an ibuprofen or two06:07
de-factowell ok i dont want to say its harmless, but its very rare (single digit numbers per million) and most do recover just fine from it, when they take it seriously enough06:09
ublxgoing back to that quote, on US numbers above, 1226 cases out of 296 million, it wouldn't exactly be mind blowing to see 1226 cases of blood vessel involvement in such a large number of vaccine administrations06:13
BrainstormNew from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): Now we have people saying they knew all along the J&J vaccine should have been two doses. Hopefully we can bury "one and done" and "experts say all the vaccines work equally well"Would have preferred that we didn't say wrong things to begin with [... want %more?] β†’ https://is.gd/Jfy2YS06:13
ublxnot that failure of intra-muscular technique is the only game in town06:16
ublx"While definitive evidence for myocarditis diagnoses is important, it is also vital that aetiology is carefully distinguished between vaccine-related myocarditis, that is rapidly resolvable with managed medical care, versus confounding an associated vaccination with other aetiology, complex co-morbidities and other co-existent medical conditions, and greater cardiovascular risk."06:16
BrainstormUpdates for Peru: +983 cases (now 2.2 million), +17 deaths (now 199792), +45938 tests (now 18.5 million) since 23 hours ago06:35
BrainstormUpdates for India: +15981 cases (now 34.1 million), +990585 tests (now 589.8 million) since 23 hours ago07:00
BrainstormNew from COVID tweets: Michael Mina (@michaelmina_lab): Problem is that we generally leave trials up to the companies producing the vaccines. So the β€œappropriate” trial data of the benefits of mRNA boost won’t be available from JJ. This is an example of where authorization efforts are sometimes confused w best public health. β†’ https://is.gd/XmsSbs07:27
BrainstormUpdates for Lombardy, Italy: +288 cases (now 888068), +4 deaths (now 34112) since a day ago β€” United Kingdom: +44374 cases (now 8.4 million) since 14 hours ago07:37
BrainstormNew from The Indian Express: World: Hate crimes and pandemic lead more Asian Americans to seek therapy β†’ https://is.gd/Oldnz307:37
cfwi!randquote08:16
sdfgsdfgs!randquote08:16
sdfgsdfgs!quote08:16
sdfgsdfgsdoesn't seem to work bro08:16
sdfgsdfgsNew from The Indian Express: World: Hate crimes and pandemic lead more Asian Americans to seek therapy08:17
sdfgsdfgslol why are indians reporting this ?08:17
sdfgsdfgsthey send more people than china to every country as "immigration" and destroy the I.T and taxi industries in those countries08:17
sdfgsdfgsso the hate crimes are probably a result of their effect and their attempt to create "little india" in every country they go08:18
sdfgsdfgsasians seeking therapy. What a funny headline08:19
BrainstormNew from The Indian Express: World: States can order Covid-19 shots for younger kids next week, says US β†’ https://is.gd/4OtmiO08:31
sdfgsdfgswish I could delete my obnoxious comments lol08:32
aanna!lastquote08:44
BrainstormNew from r/WorldNews: worldnews: Judge bans Canadian pastor who defied COVID lockdown from speaking out against gov’t rules β†’ https://is.gd/foayp608:52
BrainstormNew from r/Coronavirus: Daily Discussion Thread | October 16, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: β†’ https://is.gd/yfKf3Y09:02
BrainstormUpdates for Georgia: +5076 cases (now 657753), +44 deaths (now 9440), +62994 tests (now 9.5 million) since 23 hours ago β€” Armenia: +1863 cases (now 280294), +41 deaths (now 5754), +19360 tests (now 1.9 million) since 22 hours ago β€” Czechia: +1785 cases (now 1.7 million), +11 deaths (now 30539), +121933 tests (now 39.3 million) since 23 hours ago09:29
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Flu shots and Moderna's COVID-19 booster can be given during the same doctor's visit, Sanofi study finds β†’ https://is.gd/uwbZaf09:33
BrainstormNew from The Indian Express: World: New Zealand vaccinates 2.5% of its people in a day in drive to live with Covid-19 β†’ https://is.gd/g6qZPv09:44
BrainstormUpdates for Lithuania: +2851 cases (now 366481), +30 deaths (now 5406), +25260 tests (now 5.3 million) since a day ago10:06
BrainstormNew from The Indian Express: World: Research shows lack of trust high amid those unvaccinated in US β†’ https://is.gd/AnKOmD10:16
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 16OCT21 β†’ https://is.gd/YyMW7r10:47
BrainstormUpdates for Russia: +33208 cases (now 8.0 million), +1002 deaths (now 222315), +700000 tests (now 200.0 million) since 23 hours ago11:08
BrainstormUpdates for Poland: +3235 cases (now 2.9 million), +44 deaths (now 76111), +43645 tests (now 21.5 million) since 23 hours ago β€” Austria: +2397 cases (now 773540), +10 deaths (now 11161), +321818 tests (now 92.3 million) since a day ago β€” Slovakia: +1941 cases (now 435650), +17 deaths (now 12833), +11618 tests (now 3.8 million) since a day ago11:33
BrainstormNew from Gazzetta Ufficiale italiana: MINISTERO DELLE INFRASTRUTTURE E DELLA MOBILITA' SOSTENIBILI - DECRETO 17 agosto 2021: Assegnazione delle  risorse  alle  citta'  portuali  per  le  mancateentrate in conseguenza del calo del traffico crocieristico a  seguitodell'emergenza epidemiologica da COVID-19. (21A06002) β†’ https://is.gd/hUO0TP12:11
lastshellhttps://www.news-medical.net/amp/news/20211015/Phase-1-open-label-trial-shows-SARS-CoV-2-DNA-vaccine-induces-durable-immune-response.aspx12:27
BrainstormUpdates for Laos: +548 cases (now 31736), +2 deaths (now 38), +6602 tests (now 559426) since 20 hours ago12:35
BrainstormUpdates for Latvia: +2799 cases (now 183239), +12 deaths (now 2881), +23816 tests (now 4.7 million) since a day ago β€” Estonia: +1236 cases (now 171395), +14 deaths (now 1429), +8258 tests (now 2.0 million) since 23 hours ago β€” Indonesia: +997 cases (now 4.2 million), +44 deaths (now 142933), +270811 tests (now 43.2 million) since 23 hours ago13:00
BrainstormNew from The Indian Express: World: FDA panel endorses booster shot for J&J COVID-19 vaccine β†’ https://is.gd/eMfFeb13:25
BrainstormUpdates for Senegal: +6 cases (now 73865), +1844 tests (now 822364) since a day ago13:38
BrainstormNew from r/WorldNews: worldnews: Russia on Saturday recorded 1,000 Covid-related deaths in a single day for the first time since the pandemic began. The figure had been rising all week, with the Kremlin blaming the Russian people for not taking up vaccination. β†’ https://is.gd/YoL5pA13:46
toby000[m]Hi is anyone here interested in learning about the truth of c*vid?13:51
toby000[m]I have a reliable source that has very interesting information concerning this virus and the future of man13:51
toby000[m]If anyone here is interested feel free do send me a DM and I will tell you13:51
BrainstormUpdates for Romania: +15239 cases (now 1.4 million), +352 deaths (now 41482), +69249 tests (now 13.9 million) since a day ago β€” Bangladesh: +293 cases (now 1.6 million), +6 deaths (now 27752), +15580 tests (now 10.1 million) since 21 hours ago β€” Nepal: +136 cases (now 804652), +1 deaths (now 11278), +1446 tests (now 4.3 million) since a day ago [... want %more?]14:02
darsietoby000[m]: How do you know it's the truth?14:06
toby000[m]darsie: Its a very reliable source of information14:07
darsiek, tell me14:07
darsieWhat's the source?14:08
darsieDid someone outside the Matrix tell you?14:08
toby000[m]darsie: DM me14:09
darsiepm me14:10
darsieI have prejudice against truth.14:11
darsiepm me14:27
BrainstormNew from Reddit (test): COVID19: Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro β†’ https://is.gd/amX5cR14:28
lastshelltoby000[m] please share the "true"15:29
BrainstormUpdates for UAE: +115 cases (now 738487), +696658 tests (now 89.0 million) since 19 hours ago β€” Qatar: +69 cases (now 237867), +5066 tests (now 2.8 million) since 23 hours ago β€” United Kingdom: +44385 cases (now 8.4 million) since 21 hours ago15:30
BrainstormNew from Contagion Live: National Survey Finds Low Interest in Influenza Vaccination: New survey finds little more than half of US adults are planning to obtain vaccination against influenza despite urging by health officials. β†’ https://is.gd/SdriZg15:33
BrainstormUpdates for Belarus: +2068 cases (now 570006), +17 deaths (now 4386), +42303 tests (now 9.1 million) since a day ago β€” Saudi Arabia: +45 cases (now 547890), +2 deaths (now 8760), +43451 tests (now 29.7 million) since a day ago β€” Uganda: +45 cases (now 125094), +2 deaths (now 3182), +3982 tests (now 1.7 million) since 23 hours ago [... want %more?]16:07
lastshellthis is weird https://www.thedailybeast.com/fully-vaccinated-21-year-old-university-of-georgia-student-shawn-kuhn-dies-of-covid-1916:30
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Yep. He told us in April yet sociologists and used virus salespeople still said Delta would 'end the pandemic sooner' lol. twitter.com/PeterHotez/sta… pic.twitter.com/8XhG2JBMBH β†’ https://is.gd/hgDuxz16:36
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): And less vaccination of kids, age 12-17 pic.twitter.com/ypyKTpaNpY β†’ https://is.gd/RLcV4p16:47
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): More reliance on Astra Zeneca vaccines offered as another possible contributing factor pic.twitter.com/ohaadUWxAr β†’ https://is.gd/aLTheT16:57
BrainstormUpdates for India: +24293 cases (now 34.1 million), +223 deaths (now 452129) since 23 hours ago β€” Germany: +9161 cases (now 4.4 million), +59 deaths (now 95424) since 23 hours ago17:03
BrainstormNew from r/WorldNews: worldnews: US throws out millions of doses of Covid vaccine as world goes wanting β†’ https://is.gd/nN78ZA17:29
BrainstormUpdates for Netherlands: +3723 cases (now 2.1 million), +8 deaths (now 18674) since 15 hours ago β€” Canada: +2717 cases (now 1.7 million), +43 deaths (now 28525) since 21 hours ago17:34
LjLA Guido Rasi (former EMA director) said on a TV piece about the vaccines that "Sputnik has stopped sending us data, evidently they are no longer interested in getting it on the EU market"17:52
BrainstormUpdates for United Kingdom: +42818 cases (now 8.4 million) since 23 hours ago β€” Chile: +1688 cases (now 1.7 million), +66113 tests (now 22.7 million) since 23 hours ago17:59
BrainstormNew from Reddit (test): Saturday 16 October 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK β†’ https://is.gd/mTTWYj18:01
BrainstormNew from Reddit (test): China_Flu: Influenza lineage extinction during the COVID-19 pandemic? β†’ https://is.gd/N8uGxG18:11
LjLThey also said based on someone from Oxfam that due to inflated prices of mRNA vaccines, the EU could have saved don't know how many billions (tens), and Italy alone around 4 billions18:14
LjLBut how does that work?18:14
LjLIf a dose of Pfizer costs around €20 which is what they said18:14
LjL60 million people twice makes hundreds if million, not billions18:14
de-facto60Mln * 20€ = 2.4Bln€18:17
de-facto2* 60Mln * 20€ = 2.4Bln€18:17
de-factobtw was it not more like 12€ per BNT dose at the first contracts?18:19
de-factostill would be 1.44Bln€18:19
de-factoanyhow the costs by the pandemic are lowered by *orders* of magnitude by the vaccines18:20
de-factojust imagine one hospitalized patient costs ~10.700€ on average, severe cases 38.500€ on average18:22
de-factosource: https://www.aerztezeitung.de/Politik/Was-kostet-Corona-das-Gesundheitswesen-Kassendaten-geben-Einblick-413830.html18:23
de-factonot even beginning to talk about the costs by the load of long-COVID cases18:25
LjLWell what they said here is that with those savings we could have built 40000 ICU beds, but sure the reasoning can go both ways18:25
de-factonot only as per healthcare system but also by removing many from being productive in the economic system for extended periods of time18:25
LjLAlso someone who is against "liberating" the vaccine patents said that Moderna actually did liberate theirs but no one has announced using it, likely because no one is able to. But then they also pointed out Moderna didn't actually liberate the patent but they said they wouldn't sue companies using it during the pandemic18:26
LjL(Also, one of the countries against this is the UK, and you know, I bet producing AZ would be easier for a few companies than producing Moderna)18:27
LjL(But they didn't say that, I'm saying it)18:27
de-factoafaik the production process itself is something that is challenging e.g. how to get the mRNA into those lipid nano particles and scale that process up?18:27
LjL(But they did say that some companies claim they could produce vaccines if the patents were waived)18:27
LjLYeah that's what the ones who don't want the patents to be waived say. But then some companies, mostly not in first world countries i guess, say they could actually produce them if the patents were waived18:28
LjLI definitely have no inside knowledge to know who is right18:29
de-factoalso another point that is important in my opinion: quality control where a company stands with their name for a reliable product is kind of important, because people's trust is essential for a success in vaccination campaign18:29
de-factoso if any company could make it, it would possibly be problematic to distinguish problems that originate from lack of quality control from problems of the platform itself18:30
de-factothat may lead to decay of trust because people probably are not able to distinguish the origins of problems, they just hear about anecdotal cases of this and that and loose their trust18:32
LjLde-facto: an Indian person from MSF said the argument there is a lack of raw materials and technical abilities to make the vaccine is false and specious, and that India was forced to prioritize Indians instead of selling it to other countries when they had their crisis because only one company is authorized to produce AZ "thanks" tone patents, but in reality Asia "is the heart of pharma production" and they would be able to produce even mRNA vaccines in India if not18:33
LjLfor the patents18:33
LjLde-facto: well we could set up some scheme where a more trusted company or body would do the QA for every authorized company maybe? They said earlier at some vaccine-producing company, someone looks at each vial for 10 seconds to make sure there aren't foreign bodies or anything. Or course that's just a small part of quality control18:34
de-factoyeah i am not saying its impossible, i am only saying its something very important to ensure good quality control18:35
BrainstormUpdates for Italy: +2982 cases (now 4.7 million), +14 deaths (now 131517), +472535 tests (now 97.3 million) since 23 hours ago β€” Greece: +2301 cases (now 692197), +31 deaths (now 15348), +160399 tests (now 23.1 million) since a day ago β€” Jordan: +573 cases (now 840117), +6 deaths (now 10865), +18190 tests (now 10.5 million) since a day ago18:36
LjLIt's an argument, yeah. But then we've had batches of Moderna recalled in Japan because of metal particles in them, right?18:37
LjLThat's a pretty "crude" quality control issue18:37
LjLSo even Moderna's contracting companies couldn't do QA to the best standards18:37
de-factoyes and also the protein in AZ that originated form the cells where it was replicated18:38
de-factoits very hard to do it in a reliable and good way, already a challenge with the system we have so far18:38
LjLThey said so far the EU donated only 28 million doses to poorer countries, while the rest of what they claimed (I miss how many, maybe 80 million, maybe more?) have really been sold, and mostly to non-poor countries like Australia18:39
de-factoso it would become even more of a challenge when every company that thinks it could produce it would go ahead and throw their vaccine replica o the market18:39
LjLI am not too good at listening and also telling what I've heard at the same time :p maybe I should get the computer since I'm typing on the phone eh18:39
LjLde-facto: also some Sputnik was alleged to contain replicating virus18:40
de-factoyeah right from Brazil or such18:40
de-factook to be clear, there are some minor problems, but still i would trust in quality control and take any of those vaccines without hesitation18:41
de-facto(as i actually did)18:41
LjLuff now i lost wifi, i need to fix so many things18:42
de-facto.title https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab509/639677218:48
Brainstormde-facto: From academic.oup.com: Virologic features of SARS-CoV-2 infection in children | The Journal of Infectious Diseases | Oxford Academic18:48
de-facto"110 children with COVID-19 (median age 10 years, range 2 weeks-21 years) were included in this study. Age did not impact SARS-CoV-2 viral load. Children were most infectious within the first five days of illness, and severe disease did not correlate with increased viral loads. Pediatric SARS-CoV-2 sequences were representative of those in the community and novel variants were identified."18:49
de-facto"Symptomatic and asymptomatic children can carry high quantities of live, replicating SARS-CoV-2, creating a potential reservoir for transmission and evolution of genetic variants."18:49
de-facto"As guidance around social distancing and masking evolves following vaccine uptake in older populations, a clear understanding of SARS-CoV-2 infection dynamics in children is critical for rational development of public health policies and vaccination strategies to mitigate the impact of COVID-19."18:49
LjLde-facto, it would be interesting to know if severe disease correlates with *initial* viral load, but i guess that's much harder to find out18:56
LjLanyway i've stopped watching the TV thing18:56
LjLmaybe i'll re-watch later on RaiPlay so i can say who said what exactly instead of "this person said some millions blah blah" :P18:57
LjLi was better at translating PM speeches in semi-realtime18:57
de-factoyou did it realtime iirc18:57
de-facto.title https://jamanetwork.com/journals/jamanetworkopen/fullarticle/278491819:02
Brainstormde-facto: From jamanetwork.com: Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review | Infectious Diseases | JAMA Network Open | JAMA Network19:02
de-facto"In this systematic review of 57 studies comprising more than 250β€―000 survivors of COVID-19, most sequelae included mental health, pulmonary, and neurologic disorders, which were prevalent longer than 6 months after SARS-CoV-2 exposure."19:03
de-facto"The median (IQR) proportion of COVID-19 survivors experiencing at least 1 PASC was 54.0% (45.0%-69.0%; 13 studies) at 1 month (short-term), 55.0% (34.8%-65.5%; 38 studies) at 2 to 5 months (intermediate-term), and 54.0% (31.0%-67.0%; 9 studies) at 6 or more months (long-term)."19:03
de-factoPASC = postacute sequelae of COVID-19 aka long-COVID19:04
LjL%ca pasc19:04
BrainstormLjL, That may also be called: post-acute sequelae of COVID-19, Long COVID19:04
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Parenthetically, the antibody level increase from the 2nd J&J shot at 2 months were small relative to a booster with an mRNA vaccine (50-70 fold, 1 month)/6 pic.twitter.com/p4Ei78TLRP β†’ https://is.gd/rD6sL819:04
de-facto"Most prevalent pulmonary sequelae, neurologic disorders, mental health disorders, functional mobility impairments, and general and constitutional symptoms were chest imaging abnormality (median [IQR], 62.2% [45.8%-76.5%]), difficulty concentrating (median [IQR], 23.8% [20.4%-25.9%]), generalized anxiety disorder (median [IQR], 29.6% [14.0%-44.0%]), general functional impairments (median [IQR], 44.0% [23.4%-62.6%]), and fatigue or muscle weakness19:04
de-facto(median [IQR], 37.5% [25.4%-54.5%]), respectively."19:04
de-facto"Other frequently reported symptoms included cardiac, dermatologic, digestive, and ear, nose, and throat disorders."19:05
de-facto.title https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/278514119:08
Brainstormde-facto: From jamanetwork.com: Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members | Infectious Diseases | JAMA Internal Medicine | JAMA Network19:09
de-facto"In this cohort study of 1 789 728 individuals from 814 806 families in Sweden, family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased."19:09
de-facto"These results suggest that COVID-19 vaccines play a key role in reducing the transmission of the virus within families, which likely has implications for herd immunity and pandemic control."19:10
de-facto" To investigate the association between risk of COVID-19 in nonimmune individuals and the number of their family members with known immunity acquired from a previous COVID-19 infection or full vaccination (2 vaccine doses)."19:11
de-facto"Number of immune family members in each family on April 14, 2021 (index date), who acquired immunity from a previous COVID-19 infection or full vaccination (2 doses of the mRNA-1273, BNT162b2 mRNA, or ChAdOx1 nCoV-19 vaccine)."19:11
de-facto"Nonimmune families with 1 immune family member had a 45% to 61% lower risk of contracting COVID-19 (hazard ratio [HR], 0.39-0.55; 95% CI, 0.37-0.61, P < .001). The risk reduction increased to 75% to 86% in families with 2 immune family members (HR, 0.14-0.25; 95% CI, 0.11-0.27; P < .001), 91% to 94% with 3 immune family members (HR, 0.06-0.09; 95% CI, 0.04-0.10; P < .001), and 97% with 4 immune family members (HR, 0.03; 95% CI, 0.02-0.0519:12
de-facto; P < .001)."19:12
de-facto"The results were similar for the outcome of COVID-19 infection that was severe enough to warrant a hospital stay."19:12
de-facto"In this cohort study, family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased. Vaccination is a key strategy for decreasing the transmission of the virus within families."19:13
LjLde-facto, uhm, i think i've seen other studies had a declining rate of long COVID (don't think they called it "PASC" yet), even if not *very* declining. instead in that one it seems like it's around 55% and it stays that way? :(19:15
de-factoyeah its even a meta study19:15
LjLbut maybe chest imaging abnormality wasn't evaluated as a "symptom" in other studies if it didn't actually cause symptoms, and in this one it's the most prevalent one by far19:16
de-factovery important results imho, this will be what we are going to have to deal with for quite some time19:16
LjLsigh19:17
LjL"Furthermore, persistent symptoms (>6 weeks) have been reported in 19% of fully vaccinated individuals.8"19:18
LjLi guess that is similar to... was it 40%?19:18
LjLvaccinated long covid vs unvaccinated long covid, in the uk?19:18
leerbi%cases Switzerland19:20
Brainstormleerbi: Switzerland has had 854591 confirmed cases (10.0% of all people) and 11171 deaths (1.3% of cases) as of 17 hours ago. 11.3 million tests were done (7.6% positive). 5.6 million were vaccinated (65.7%). +1 deaths since 10 hours ago. See https://offloop.net/covid19/?default=Switzerland19:20
Brainstormleerbi: If you know of an official or otherwise good site for data about Switzerland, with a reasonably short URL, please %tell LjL about it.19:20
leerbi%cases Russia19:20
Brainstormleerbi: Russia has had 8.0 million confirmed cases (5.4% of all people) and 222315 deaths (2.8% of cases) as of 8 hours ago. 200.0 million tests were done (4.0% positive). 50.2 million were vaccinated (34.2%). +33208 cases, +1002 deaths, +700000 tests since 23 hours ago. See https://offloop.net/covid19/?default=Russia19:21
Brainstormleerbi: If you know of an official or otherwise good site for data about Russia, with a reasonably short URL, please %tell LjL about it.19:21
LjLfor the record, i highly doubt Russia's case count is "honest"19:29
LjL(also lol did they do exactly 700000 tests?)19:30
leerbiLjL, thanks. It's a pity but i think you're right.19:34
LjLat some point the deaths were staying very suspiciously just below 800 a day. it didn't look "natural"19:35
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Singapore has begun the descent from its Delta wave, which took its toll beyond a high case burdencovidsitrep.moh.gov.sg@OurWorldInData pic.twitter.com/3ib5jcKOYW β†’ https://is.gd/hLjiov19:35
LjLsingapore has *begun* the descent? yikes, i'm scared to check how high they went, i haven't checked in some time but it was definitely climbing19:37
LjL%cases singapore19:37
BrainstormUpdates for Canada: +2660 cases (now 1.7 million) since 22 hours ago19:37
BrainstormLjL: Singapore has had 141772 confirmed cases (2.5% of all people) and 215 deaths (0.2% of cases) as of 21 hours ago. 20.4 million tests were done (0.7% positive). 4.7 million were vaccinated (82.9%). +3445 cases, +8 deaths since a day ago. See https://offloop.net/covid19/?default=Singapore19:37
LjLbut still... compare the deaths with pre-vaccine rates in both countries https://offloop.net/covid19/?default=Italy;Singapore&byPopulation=yes&cumulative=no&smooth=yes19:39
LjLas i was saying yesterday, these vaccines are not satisfactory, because it's still circulating (hence mutating including to evade the vaccine, since no sterile immunity) and because a spike like Singapore's still causes uncomfortably many deaths. but... they're A LOT better than nothing.19:40
LjLalthough, i dunno19:43
LjLcompared to Italy's death rate in the pre-vaccine waves, it's much better19:43
LjLbut Singapore itself had a moderately high amount of cases in 2020 yet the deaths were so low19:44
LjLbut see the second graph posted by Topol https://twitter.com/EricTopol/status/1449426542157647873/photo/219:44
LjLa lot of people did end up in ICU in that first wave, but... evidently, they didn't die...?19:44
LjLit's a similar amount of people in ICU as this time, but this time they died too19:44
LjLi posted https://twitter.com/BrainstormBot/status/144943210913169818319:48
LjLde-facto, something to note maybe in that review of "PASC", "197β€―777 (79%) were hospitalized during acute COVID-19" so it's from studies with a high rate of hospitalization19:51
LjLthere may be lower amounts of pulmonary findings in people with at-home COVID19:51
LjLso i also posted https://twitter.com/BrainstormBot/status/144943364260279910619:54
LjLi doubt Topol has the time to reply to me though :P and other people tend to reply a bit randomly in those threads. Brian Hjalle did reply to me yesterday19:55
LjLerr, that's his name, right? why is he not showing up on my Twitter anymore O.o19:56
BrainstormNew from r/WorldNews: worldnews: Alberta's reporting of comorbidities questioned after boy, 14, removed from COVID-19 death count β†’ https://is.gd/uz13z119:56
LjLa second ago i had a post from him in my homepage, then it went away and now if i search for him nothing shows up19:57
LjLoh Hjelle duh19:57
LjLstill, he has 13k followers, which is a lot for *my* standards, but Topol has 532k :D19:58
LjLlooks like with so many studies, that review may have made some mistakes: https://twitter.com/YuryGruz/status/144838183786533274220:01
LjLbut also like it may not matter for the bulk of the data20:01
LjL(if you scroll up, that's a subthread from someone also pointing out 79% were hospitalized)20:02
BrainstormUpdates for Dominican Rep.: +870 cases (now 369700), +2 deaths (now 4084), +5134 tests (now 2.1 million) since a day ago β€” Maldives: +111 cases (now 86088), +4614 tests (now 1.6 million) since a day ago β€” Burkina Faso: +29 cases (now 14686), +540 tests (now 221012) since 20 hours ago20:03
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Spike gene (light green below) is a small part of the SARS2 genome. It is very important in immunity, no doubt. But T cells recognize more "buried" proteins that are made elsewhere in the genome. They even recognize the small amounts of replicative enzymes of viruses, in cells... pic.twitter.com/DxIo3hAFWo β†’ https://is.gd/CP3cpw20:07
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Just published at @CellCellPress The pivotal importance of vaccine dose spacing. Comparison of a median 3.3 week vs 10.1 week spacing for the Pfizer vaccine shows longer lag yields much higher neutralizing antibody and CD4+ T cell responsecell.com/cell/fulltext/… Delta exampleπŸ‘‡ pic.twitter.com/Vv30vmxbhV β†’ https://is.gd/t0iDWA20:17
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review ( https://www.zotero.org/groups/covid_links/items/XAXKD5D6 )20:19
Arsanerit%cases Portugal20:38
BrainstormArsanerit: Portugal has had 1.1 million confirmed cases (10.5% of all people) and 18088 deaths (1.7% of cases) as of 3 hours ago. 19.2 million tests were done (5.6% positive). 9.0 million were vaccinated (87.3%). +612 cases, +10 deaths since a day ago. See https://offloop.net/covid19/?default=Portugal20:38
BrainstormArsanerit: If you know of an official or otherwise good site for data about Portugal, with a reasonably short URL, please %tell LjL about it.20:38
Arsanerit%cases Gibraltar20:38
BrainstormArsanerit: Gibraltar has had 5751 confirmed cases (17.1% of all people) and 98 deaths (1.7% of cases) as of 6 hours ago. 374669 tests were done (1.5% positive). 39970 were vaccinated (118.6%). +11 cases, +792 tests since 21 hours ago. See https://offloop.net/covid19/?default=Gibraltar20:38
BrainstormArsanerit: If you know of an official or otherwise good site for data about Gibraltar, with a reasonably short URL, please %tell LjL about it.20:38
Arsanerit118.6% vaccinated, not bad!20:38
ArsaneritHow did they do that?20:38
LjLit's doses/residents20:38
LjLmost vaccines have two doses, so...20:39
LjLi guess "were vaccinated" is not the best phrasing there20:39
LjLi made the phrasing shorter a while ago to make more stuff fit, but it really should be "vaccine doses were administered"20:39
LjL(administrated?)20:39
ArsaneritI see, that makes sense.20:40
LjLwait no20:40
LjLfor Portugal it's actually amount of vaccinated people20:40
LjLso uh20:40
* LjL looks at the code20:40
BrainstormUpdates for India: +14051 cases (now 34.1 million), +148 deaths (now 452156) since 22 hours ago20:40
LjLactually no, i am already looking at earthquake code, i must force myself to do one thing at a time :P20:40
ArsaneritPoor Croatia.20:44
LjLArsanerit, i assume they got the same allotment of vaccines as the rest of the EU... if they don't get vaccinated, yes, sorry for them, but they're kinda not helping themselves :\20:56
ArsaneritI was thinking about them having been hit by an earthquake in the middle of the first wave last year.21:00
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): We've known about the lapses in antibody levels and reduced protection vs hospitalization for some time, but left these people (who typically had no choice and were told all vaccines were equivalent) susceptible over a prolonged period pic.twitter.com/MIvB3lF3xc β†’ https://is.gd/TEYEqR21:20
LjLde-facto, look at the vaccine efficacy against hospitalization of J&J in the tweet above (second image)21:41
LjLand he's right, that's one of the things that i don't like as i was saying yesterday... yes, *here*, we know that not all vaccines are equivalent, the information exist. but media and governments basically said "they're all effective, get any of them", which is true but also not the whole truth21:42
LjLpity we can't compare to AZ21:42
LjLa vaccine efficacy *against hospitalization* of 60% is not good. let's stop saying they're all good.21:43
LjLand with a large confidence interval the upper value of which is *still low*21:43
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): And sure enough, veteran study preprint indicates that while antibody responses persisted, protection did not. They were dissociated.We absolutely need some way to predict protection and act pre-emptively, before virus gets you.It's been tough.END β†’ https://is.gd/KmhZrG21:52
BrainstormNew from COVID tweets: Marc Veldhoen (@Marc_Veld): An extended interval between doses is highly protectiveAntibody levels higher after the extended regimen compared to the short regimenAntibody levels wane after each dose but B and T cell pools maintained β†’ https://is.gd/9Qmdkm22:02
de-facto.title https://www.sciencedirect.com/science/article/pii/S009286742101221622:03
Brainstormde-facto: From www.sciencedirect.com: Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine - ScienceDirect22:03
de-facto.title https://www.medrxiv.org/content/10.1101/2021.10.13.21264966v122:06
Brainstormde-facto: From www.medrxiv.org: Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 | medRxiv22:06
BrainstormNew from COVID tweets: Bernie Sanders (@BernieSanders): Please get vaccinated. β†’ https://is.gd/Bzy5pA22:23
de-factobtw the medrxiv paper is the one where Topol stole the nice comparison for decay rates of vaccinations from https://pbs.twimg.com/media/FB1X-xYVIAIhmTk?format=jpg&name=large,22:25
de-factofound it via image search and backtracking22:26
BrainstormNew from COVID tweets: Prof Francois Balloux (@BallouxFrancois): I appreciate many mainstream American public health practitioners believe their discipline is deeply political, a belief often shared by their critiques. Though, to have let COVID-19 vaccination to become a 'party-political' issue is a disaster, and a pox on both their houses. β†’ https://is.gd/RlcbhP23:05
BrainstormUpdates for Kuwait: +39 cases (now 412297), +1 deaths (now 2456), +14688 tests (now 4.6 million) since a day ago23:35
BrainstormNew from COVID tweets: Josiah Grindrod (@JT_Grindrod): @fitterhappierAJ maybe if they infected the mice with OC43 before infecting them with SARS-CoV-2 πŸ™„ok i'll stop β†’ https://is.gd/2Az4cx23:47
BrainstormUpdates for Germany: +8515 cases (now 4.4 million), +28 deaths (now 95444) since 23 hours ago β€” Bahrain: +55 cases (now 276030), +15042 tests (now 6.7 million) since 23 hours ago23:59

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