libera/##covid-19/ Saturday, 2021-11-06

de-facto.title https://papers.ssrn.com/sol3/papers.cfm?abstract_id=394941000:00
Brainstormde-facto: From papers.ssrn.com: Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study by Peter Nordström, Marcel Ballin, Anna Nordström :: SSRN00:00
de-facto"A retrospective cohort study was conducted using Swedish nationwide registries. The cohort comprised 842,974 pairs (N=1,684,958), including individuals vaccinated with 2 doses of ChAdOx1 nCoV-19, mRNA-1273, or BNT162b2, and matched unvaccinated individuals. "00:00
de-facto"Cases of symptomatic infection and severe Covid-19 (hospitalization or 30-day mortality after confirmed infection) were collected from 12 January to 4 October 2021. "00:00
de-facto"Vaccine effectiveness of BNT162b2 against infection waned progressively from 92% (95% CI, 92-93, P<0·001) at day 15-30 to 47% (95% CI, 39-55, P<0·001) at day 121-180, and from day 211 and onwards no effectiveness could be detected (23%; 95% CI, -2-41, P=0·07). The effectiveness waned slightly slower for mRNA-1273, being estimated to 59% (95% CI, 18-79) from day 181 and onwards."00:01
de-facto"In contrast, effectiveness of ChAdOx1 nCoV-19 was generally lower and waned faster, with no effectiveness detected from day 121 and onwards (-19%, 95% CI, -97-28), whereas effectiveness from heterologous ChAdOx1 nCoV-19 / mRNA was maintained from 121 days and onwards (66%; 95% CI, 41-80)."00:01
de-facto"Overall, vaccine effectiveness was lower and waned faster among men and older individuals. For the outcome severe Covid-19, effectiveness waned from 89% (95% CI, 82-93, P<0·001) at day 15-30 to 42% (95% CI, -35-75, P=0·21) from day 181 and onwards, with sensitivity analyses showing notable waning among men, older frail individuals, and individuals with comorbidities."00:01
Dreddde-facto: Damn, only 4 months for me ☹️00:20
DreddBy that logic I am currently unprotected again00:20
DreddI don't think other studies have been quite so pessimistic in their findings?00:21
Dredd.title https://www.nature.com/articles/s41598-021-00794-600:21
BrainstormDredd: From www.nature.com: COVID-19 vaccine acceptance among adults in four major US metropolitan areas and nationwide | Scientific Reports00:21
BrainstormUpdates for Bulgaria: +4734 cases (now 628680), +185 deaths (now 24940), +40083 tests (now 5.8 million) since a day ago00:34
de-factoDredd, i am not sure how Sweden scheduled the delay between primer and booster though, that may potentially play a role in half-life of nABs00:35
de-facto"Another interesting finding from the present study was that vaccine effectiveness from heterologous ChAdOx1 nCoV-19 / mRNA schedules seemed to be better maintained than that from homologous ChAdOx1 nCoV-19 vaccination."00:43
de-factothere loads of quite interesting datapoints in their tables00:47
BrainstormUpdates for Nigeria: +65 cases (now 212511), +41347 tests (now 3.3 million) since 22 hours ago — Namibia: +18 cases (now 128985), +2 deaths (now 3560), +1762 tests (now 757005) since a day ago00:59
BrainstormUpdates for Bermuda: +12 cases (now 5677), +3548 tests (now 606909) since a day ago — Curacao: +11 cases (now 17134), +862 tests (now 317929) since 22 hours ago02:01
BrainstormUpdates for Canada: +2503 cases (now 1.7 million), +16 deaths (now 29185), +99061 tests (now 46.7 million) since 23 hours ago — Faroe Is.: +54 cases (now 2538), +3000 tests (now 502000) since a day ago02:39
BrainstormNew from r/Science: science: Pfizer says COVID-19 pill cut hospital, death risk by 90% → https://old.reddit.com/r/science/comments/qnqdtx/pfizer_says_covid19_pill_cut_hospital_death_risk/03:25
BrainstormUpdates for United Kingdom: +33974 cases (now 9.3 million) since 23 hours ago — Netherlands: +10976 cases (now 2.2 million), +21 deaths (now 18958) since 23 hours ago03:41
BrainstormNew from The Indian Express: World: Pfizer CEO in talks with 90 countries for Covid-19 pill → https://indianexpress.com/article/world/pfizer-covid-19-pill-world-supply-7609554/03:58
BrainstormUpdates for Bolivia: +976 cases (now 517229), +9 deaths (now 18960), +7879 tests (now 2.6 million) since 3 hours ago04:30
BrainstormNew from The Indian Express: World: Pfizer says its antiviral pill slashes risk of severe Covid-19 by 89% → https://indianexpress.com/article/world/pfizer-says-its-antiviral-pill-slashes-risk-of-severe-covid-19-by-89-7609595/05:11
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): How the deer are getting covid:Entering shops without masks twitter.com/Julidooty/stat… → https://twitter.com/fitterhappierAJ/status/145683966158694400205:32
BrainstormUpdates for Germany: +33781 cases (now 4.8 million) since 18 hours ago05:33
steeltormentor[mhi, wanna ask about molnupiravir and paxlovid: are these two similar in the way they work?05:43
steeltormentor[mi read some articles saying both are virus inhibitors05:43
steeltormentor[mhowever I'm intrigued to the difference in efficacy between the two05:44
BrainstormUpdates for Peru: +1062 cases (now 2.2 million), +23 deaths (now 200373), +47404 tests (now 19.3 million) since a day ago06:04
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Endemic SARS-Cov-2 means Vaxx + mask twitter.com/lukeliao1/stat… pic.twitter.com/gaRmHO1Gqe → https://twitter.com/fitterhappierAJ/status/145684696515371417906:04
BrainstormNew from r/WorldNews: worldnews: Chinese journalist jailed over Covid reports ‘close to death’ → https://old.reddit.com/r/worldnews/comments/qntdqi/chinese_journalist_jailed_over_covid_reports/06:25
BrainstormUpdates for Zakarpattia Oblast, Ukraine: +469 cases (now 70733), +12 deaths (now 1795) since a day ago — San Andres y Providencia, Colombia: +45 cases (now 7215) since a day ago — Lombardy, Italy: +840 cases (now 897249), +7 deaths (now 34194) since a day ago — India: +10929 cases (now 34.3 million) since 23 hours ago06:35
BrainstormNew from r/WorldNews: worldnews: New Zealand hits Covid case record but Ardern says ‘better times coming’ → https://old.reddit.com/r/worldnews/comments/qnud6p/new_zealand_hits_covid_case_record_but_ardern/07:48
BrainstormNew from The Indian Express: World: Trapped in a pandemic funk: Millions of Americans can’t shake a gloomy outlook → https://indianexpress.com/article/world/trapped-in-a-pandemic-funk-millions-of-americans-cant-shake-a-gloomy-outlook-7609746/07:58
BrainstormNew from r/Coronavirus: Daily Discussion Thread | November 06, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/qnuwf7/daily_discussion_thread_november_06_2021/08:09
sifisega2anyone losing a job in au/nz?08:17
BrainstormNew from The Indian Express: World: Australia hits ‘magnificent milestone’ with 80% rate of vaccinations → https://indianexpress.com/article/world/australia-milestone-80-rate-of-covid-19-vaccinations-7609753/08:29
BrainstormNew from The Indian Express: World: Near-daily Covid-19 tests, sleeping in classrooms: Life in Covid-zero China → https://indianexpress.com/article/world/near-daily-covid-19-tests-sleeping-in-classrooms-life-in-covid-zero-china-7609863/08:51
BrainstormNew from The Indian Express (Health): Life-style: In Naples, Three Wise Men get Covid health pass to visit Jesus’ manger → https://indianexpress.com/article/lifestyle/life-style/in-naples-three-wise-men-get-covid-health-pass-to-visit-jesus-manger-7608945/09:01
BrainstormUpdates for Czechia: +9241 cases (now 1.8 million), +47 deaths (now 30985), +116366 tests (now 41.1 million) since 23 hours ago — Georgia: +5240 cases (now 748751), +68 deaths (now 10368), +53544 tests (now 10.5 million) since a day ago — Armenia: +2177 cases (now 319016), +46 deaths (now 6628), +10469 tests (now 2.2 million) since 23 hours ago09:10
BrainstormUpdates for Lithuania: +3524 cases (now 424884), +37 deaths (now 6084), +7270 vaccines (now 1.8 million), +23542 tests (now 5.7 million) since 23 hours ago — Taiwan: +1 cases (now 16438), +37334 vaccines (now 17.4 million) since 23 hours ago10:00
BrainstormNew from r/WorldNews: worldnews: Norway Introduces Quarantine for Arrivals From Regions of Greece, Denmark, Sweden & Finland → https://old.reddit.com/r/worldnews/comments/qnw6h1/norway_introduces_quarantine_for_arrivals_from/10:13
BrainstormNew from COVID tweets: Marc Veldhoen (@Marc_Veld): Current science funding is a complicated and expensive procedure. "Scientists spend up to 40 percent of their time working on research grants rather than on research." The pandemic may have provided an alternative option.theatlantic.com/ideas/archive/… → https://twitter.com/Marc_Veld/status/145691332873603072210:24
BrainstormUpdates for Estonia: +1519 cases (now 204148), +17 deaths (now 1598), +8493 tests (now 2.2 million) since 23 hours ago — Germany: +33785 cases (now 4.8 million) since 23 hours ago10:37
BrainstormUpdates for Austria: +9943 cases (now 875333), +31 deaths (now 11482), +414915 tests (now 99.9 million) since a day ago — Slovakia: +6502 cases (now 513297), +39 deaths (now 13205), +21305 tests (now 4.1 million) since 23 hours ago11:08
BrainstormNew from The Indian Express: World: New Zealand’s daily Covid-19 cases cross 200 for first time in pandemic → https://indianexpress.com/article/world/new-zealand-daily-covid-19-cases-cross-200-delta-variant-7609996/11:16
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: EXPLAINER: What the COVID-19 vaccine mandate means for firms and workers → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/qnxj6w/explainer_what_the_covid19_vaccine_mandate_means/11:36
BrainstormNew from r/WorldNews: worldnews: Doctors say homeopathic treatment Rodgers reportedly received is not an alternative to COVID-19 vaccine → https://old.reddit.com/r/worldnews/comments/qnxuua/doctors_say_homeopathic_treatment_rodgers/12:08
BrainstormUpdates for Poland: +15195 cases (now 3.1 million), +186 deaths (now 77733), +77986 tests (now 22.6 million) since a day ago — Latvia: +1888 cases (now 230569), +28 deaths (now 3472), +23906 tests (now 5.1 million) since 20 hours ago — Laos: +960 cases (now 45980), +4 deaths (now 81), +7233 tests (now 681236) since 22 hours ago [... want %more?]12:11
BrainstormUpdates for Brunei: +197 cases (now 13742), +2 deaths (now 93), +6838 tests (now 528665) since 2 days ago — Zimbabwe: +34 cases (now 133146), +3228 tests (now 1.5 million) since a day ago12:42
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): At least 8 people didn't get COVID at Travis Scott show.😥 → https://twitter.com/hjelle_brian/status/145695008443263386412:51
purplesail[m]%cases Ukraine13:10
Brainstormpurplesail[m]: Ukraine has had 3.2 million confirmed cases (7.6% of all people) and 76175 deaths (2.4% of cases) as of an hour ago. 14.8 million tests were done (21.6% positive). 11.3 million were vaccinated (26.9%). +26181 cases, +826 deaths since 23 hours ago. See https://covid19.rnbo.gov.ua/13:10
purplesail[m]%cases UK13:11
BrainstormUpdates for Zambia: +17 cases (now 209869), +1 deaths (now 3663), +4996 tests (now 2.6 million) since 23 hours ago13:12
Brainstormpurplesail[m]: United Kingdom has had 9.3 million confirmed cases (14.0% of all people) and 142019 deaths (1.5% of cases) as of 9 hours ago. 338.3 million tests were done (2.7% positive). 50.2 million were vaccinated (75.5%). +33974 cases since 23 hours ago. See https://coronavirus.data.gov.uk/13:12
BrainstormNew from r/WorldNews: worldnews: Australia hits 'magnificent milestone' with 80% rate of vaccinations → https://old.reddit.com/r/worldnews/comments/qnypmi/australia_hits_magnificent_milestone_with_80_rate/13:13
BrainstormNew from r/WorldNews: worldnews: New coronavirus, likely from dogs, could be 8th coronavirus to spread in humans → https://old.reddit.com/r/worldnews/comments/qnz3b3/new_coronavirus_likely_from_dogs_could_be_8th/13:35
BrainstormUpdates for Gibraltar: +23 cases (now 6138), +907 tests (now 391163) since 22 hours ago13:38
de-facto.title https://en.wikipedia.org/wiki/Molnupiravir13:52
Brainstormde-facto: From en.wikipedia.org: Molnupiravir - Wikipedia13:52
de-facto"Molnupiravir is a prodrug of the synthetic nucleoside derivative N4-hydroxycytidine (also called EIDD-1931), and exerts its antiviral action through introduction of copying errors during viral RNA replication."13:52
de-facto.title https://en.wikipedia.org/wiki/PF-0732133213:52
Brainstormde-facto: From en.wikipedia.org: PF-07321332 - Wikipedia13:52
de-facto"PF-07321332 is an antiviral drug developed by Pfizer which acts as an orally active 3CL protease inhibitor. It is a covalent inhibitor, binding directly to the catalytic cysteine (Cys145) residue of the enzyme. As Paxlovid, it is in phase 3 trials for the treatment of COVID-19 in combination with ritonavir."13:53
BrainstormUpdates for Cayman Is.: +194 cases (now 2676) since a day ago — Croatia: +7094 cases (now 497168), +50 deaths (now 9450), +15498 tests (now 3.2 million) since a day ago — Bangladesh: +350 cases (now 1.6 million), +4 deaths (now 27891), +30518 tests (now 10.5 million) since 2 days ago — Qatar: +124 cases (now 239995), +5832 tests (now 2.9 million) since 23 hours ago14:02
BrainstormNew from Politico: Germany post-Merkel won’t return to lockdowns, coalition partner vows: Christian Lindner, Germany's likely next finance minister, made the pledge amid a record spike in COVID-19 cases. → https://www.politico.eu/article/germany-lockdown-coronavirus-fdp-christian-lindner/14:08
BrainstormNew from Reddit (test): nCoV: Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study | 05NOV21 → https://old.reddit.com/r/nCoV/comments/qo057z/pfizers_novel_covid19_oral_antiviral_treatment/14:30
BrainstormNew from Reddit (test): Covid2019: McMaster researchers investigate causes of long COVID: he New England Journal of Medicine says the long-term impacts of COVID-19 will be the next big national disaster in the United States. We are looking at a similar situation north of the border,” → https://old.reddit.com/r/Covid2019/comments/qo0628/mcmaster_researchers_investigate_causes_of_long/14:41
BrainstormUpdates for Belgium: +10915 cases (now 1.4 million), +26 deaths (now 26131), +99904 tests (now 22.2 million) since a day ago — Germany: +34077 cases (now 4.8 million) since 22 hours ago — UAE: +73 cases (now 740362), +1 deaths (now 2139), +281138 tests (now 94.9 million) since 23 hours ago — United Kingdom: +33845 cases (now 9.3 million) since 22 hours ago14:46
BrainstormNew from The Indian Express: World: Austria to bar unvaccinated from restaurants as cases rise → https://indianexpress.com/article/world/austria-unvaccinated-restaurants-cases-rise-7610390/15:15
BrainstormUpdates for Belarus: +1993 cases (now 612015), +18 deaths (now 4730), +32421 tests (now 9.8 million) since a day ago — Saudi Arabia: +42 cases (now 548890), +1 deaths (now 8803), +35230 tests (now 30.6 million) since a day ago15:17
BrainstormUpdates for Canada: +2474 cases (now 1.7 million) since 22 hours ago15:30
BrainstormNew from r/WorldNews: worldnews: COVID Victoria: Australia hits 80% vaccination target as Victoria records 1268 new cases, seven deaths → https://old.reddit.com/r/worldnews/comments/qo1hov/covid_victoria_australia_hits_80_vaccination/15:48
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): A few updates Price for Paxlovid is to be same as Molnupiravir, which is disappointing nytimes.com/2021/11/05/hea… by @RebeccaDRobbins Origin of Molnupiravirnature.com/articles/d4158…Worth highlighting that these pills would not be expected to be affected by [... want %more?] → https://twitter.com/EricTopol/status/145700061868649677316:09
BrainstormUpdates for Chile: +2796 cases (now 1.7 million), +27 deaths (now 37841), +82419 tests (now 23.9 million) since a day ago — India: +2 deaths (now 460270) since 16 hours ago16:13
BrainstormUpdates for Uganda: +85 cases (now 126492), +2 deaths (now 3226), +6228 tests (now 1.8 million) since a day ago16:38
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): UK Covid wave abating"The rolling weekly average of daily Covid cases in the UK peaked at about 47,000 on October 19 and is now below 40,000." Boosters are having a benefit in advanced age group  (1st to receive 3rd shots)ft.com/content/8f7509… graph by [... want %more?] → https://twitter.com/EricTopol/status/145700912772553933416:42
BrainstormUpdates for Jordan: +1122 cases (now 873707), +12 deaths (now 11114), +19024 tests (now 11.2 million) since a day ago17:03
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Dunno if we'll get DNA vaccines in humans soon (so far many efforts to nada) but a (somewhat) heterologous target "variant" antigen as boost makes this an interesting approach. We need to at least TRY to cover variants. Viruses that AREN'T extinct? [... want %more?] → https://twitter.com/hjelle_brian/status/145702265797982617917:36
BrainstormUpdates for Netherlands: +11995 cases (now 2.2 million), +37 deaths (now 18994) since 21 hours ago17:40
BrainstormNew from Reddit (test): CoronavirusUK: Saturday 06 November 2021 Update → https://old.reddit.com/r/CoronavirusUK/comments/qo3voi/saturday_06_november_2021_update/17:48
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): These tough guys, rest assured, enjoy unfettered access to the latest COVID drugs rest of us have never heard of, case they get a triple-vax breakthru. All on public dime. twitter.com/RonFilipkowski… → https://twitter.com/hjelle_brian/status/145702686993759846617:59
BrainstormUpdates for Italy: +6760 cases (now 4.8 million), +31 deaths (now 132365), +491962 tests (now 106.9 million) since 23 hours ago — Greece: +6356 cases (now 780621), +43 deaths (now 16243), +284452 tests (now 27.5 million) since a day ago — Canada: +2482 cases (now 1.7 million) since 23 hours ago18:30
BrainstormNew from r/WorldNews: worldnews: COVID: German health chiefs call for stricter curbs → https://old.reddit.com/r/worldnews/comments/qo4msv/covid_german_health_chiefs_call_for_stricter_curbs/18:31
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Future of Covid vaccines, w/ lessens from flu, on antigenic drift & waning immunitynejm.org/doi/full/10.10… @NEJM by @arnold_montoThe effect on asymptomatic infections was a welcome surprise, because it has been thought that most vaccines for respiratory [... want %more?] → https://twitter.com/EricTopol/status/145703755942765364018:42
BrainstormUpdates for Dominican Rep.: +984 cases (now 387269), +2 deaths (now 4150), +8844 tests (now 2.3 million) since a day ago19:01
BrainstormUpdates for United Kingdom: +30367 cases (now 9.3 million), +155 deaths (now 142174) since 15 hours ago — India: +915 cases (now 34.3 million), +15 deaths (now 460283) since 20 hours ago — Maldives: +119 cases (now 88635), +3685 tests (now 1.6 million) since 21 hours ago19:38
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): People asking if deer get sick from COVID and I wanna know too.Didja know that's a BSL3 experiment and yall can't just start infecting deer at the deer farm, see what happens?There are very few places that can do that experiment. Maybe CSU Ft Collins. → https://twitter.com/hjelle_brian/status/145705459893856666119:48
BrainstormNew from COVID tweets: Tom Wenseleers (@TWenseleers): Ongevaccineerden belasten intensieve zorg onevenredig zwaar standaard.be/cnt/dmf2021110… via @destandaard pic.twitter.com/22zjGnJ7yj → https://twitter.com/TWenseleers/status/145707262171623014920:53
BrainstormUpdates for Canada: +2390 cases (now 1.7 million), +11 deaths (now 29189) since 23 hours ago — France: +408 cases (now 7.3 million), +25 deaths (now 118855) since 23 hours ago21:36
BrainstormUpdates for Germany: +33517 cases (now 4.8 million), +122 deaths (now 97019) since 23 hours ago22:01
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): The reason we can't know easily if deer are getting sick from SARS2 infection is cuz they're wildlife. They live most of life unseen by us. If one dies in the woods, we usually don't even know. They could be breezing thru it or or suffering serious mortality. → https://twitter.com/hjelle_brian/status/145709389764600217722:20
BrainstormNew from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): It would be foolish to presume:*ANY white tail deer population is spared from the SARS2 epizootic*You can't catch COVID from a deer → https://twitter.com/hjelle_brian/status/145709607318123725022:30
BrainstormUpdates for India: +10879 cases (now 34.4 million), +519 deaths (now 460787) since 23 hours ago — Mali: +48 cases (now 16342), +3 deaths (now 574), +1233 tests (now 461525) since 23 hours ago — Kuwait: +28 cases (now 412821), +14262 tests (now 4.9 million) since a day ago22:39
BrainstormUpdates for Rwanda: +33 cases (now 99931), +39109 tests (now 3.2 million) since 23 hours ago — Bahrain: +30 cases (now 277041), +16810 tests (now 7.0 million) since 23 hours ago23:04
BrainstormUpdates for Netherlands: +11970 cases (now 2.2 million) since 20 hours ago23:41
BrainstormNew from The Indian Express: World: COP in Covid: Managing record crowds  and commitment with pandemic protocol → https://indianexpress.com/article/world/cop26-climate-change-glasgow-conference-covid-protocol-7610694/23:46

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